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64Cu labeled phtoimmunotherapy to targeting cancer cell

Research Project

Project/Area Number 26461845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

Nakajima Takahito  群馬大学, 大学院医学系研究科, 特任准教授 (70375559)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords光免疫療法 / 近赤外線 / 抗体 / IRDye700 / 癌治療 / 分子イメージング / 蛍光 / ポジトロン核種
Outline of Final Research Achievements

Photoimmunotherapy is a novel treatment method for cancers. The conjugates of antibody and IRDye700 are administrated and then near infrared light is irradiated to the tumor. Since near infrared light is not harmful to normal tissue, photoimmunotherapy can damage only to cancer cells. Near infrared light will reach only the shallow area and this therapy will be applied for head and neck cancers. However, in the near future, photoimmunotherapy can be applied for cancers in deep areas of body with the support of Interventional technique.
In this study, we employed Cu-64, a positron emission tracer, to label the conjugate. And we acquired images of tumor bearing mice by a PET scanner. Cu-64 accumulation was seen in a tumor. Our method would be promising for the evaluation of the conjugate distribution before photoimmunotheraphy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 6 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Advantages of L-3-[(18)F] fluoro-alpha-methyl tyrosine over 2-[(18)F]-fluoro-2-deoxyglucose in detecting liver metastasis during positron emission tomography scan2016

    • Author(s)
      Kodaira S, Nakajima T, Arisaka Y, Tokue A, Higuchi T, Tsushima Y.
    • Journal Title

      Springerplus

      Volume: 5 Issue: 1 Pages: 618-618

    • DOI

      10.1186/s40064-016-2212-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy.2016

    • Author(s)
      Sato K, Watanabe R, Hanaoka H, Nakajima T, Choyke PL, Kobayashi H.
    • Journal Title

      Oncotarget

      Volume: 7(12) Issue: 12 Pages: 14324-35

    • DOI

      10.18632/oncotarget.7365

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Photoimmunotherapy of hepatocellular carcinoma-targeting Glypican-3 combined with nanosized albumin-bound paclitaxel.2015

    • Author(s)
      Hanaoka H, Nakajima T, Sato K, Watanabe R, Phung Y, Gao W, Harada T, Kim I, Paik CH, Choyke PL, Ho M, Kobayashi H.
    • Journal Title

      Nanomedicine

      Volume: 10 Issue: 7 Pages: 1139-1147

    • DOI

      10.2217/nnm.14.194

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine.2015

    • Author(s)
      Sato K, Nakajima T, Choyke PL, Kobayashi H.
    • Journal Title

      RSC Advances

      Volume: 5 Issue: 32 Pages: 25105-25114

    • DOI

      10.1039/c4ra13835j

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovariancancer.2015

    • Author(s)
      Sato K, Hanaoka H, Watanabe R, Nakajima T, Choyke PL, Kobayashi H.
    • Journal Title

      Mol Cancer Ther.

      Volume: 14 Issue: 1 Pages: 141-50

    • DOI

      10.1158/1535-7163.mct-14-0658

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer.2015

    • Author(s)
      Sato K, Hanaoka H, Watanabe R, Nakajima T, Choyke PL, Kobayashi H.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 14 Pages: 141-150

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity.2014

    • Author(s)
      Nakajima T, Sato K, Hanaoka H, Watanabe R, Harada T, Choyke PL, Kobayashi H.
    • Journal Title

      BMC Cancer

      Volume: 14 Issue: 1

    • DOI

      10.1186/1471-2407-14-389

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic fluorescent imaging with indocyanine green for monitoring the therapeutic effects of photoimmunotherapy.2014

    • Author(s)
      Ali T, Nakajima T, Sano K, Sato K, Choyke PL, Kobayashi H.
    • Journal Title

      Contrast Media & Molecular Imaging

      Volume: 9 Issue: 4 Pages: 276-82

    • DOI

      10.1002/cmmi.1570

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] A novel parameter to evaluate thyroid function with dual-energy CT in patients with hyperthyroidism,2017

    • Author(s)
      Nakajima T, Otake H, Binh DD, Higuchi T, Tsushima Y.
    • Organizer
      European congress of radiology
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of EGFR Positive Lung Squamous Cell Carcinoma by Activatable Fluorescence Imaging.2016

    • Author(s)
      Zhang X, Kim M, Nakajima T, Yamaguchi A, Houng NT, Gu WC, Yusri DH, Tsushima Y.
    • Organizer
      11th Symosium of the Scandinavian Japanese Radiological Society & 14th Nordic & Japan PACS Symposium.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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