Development of patient specific medicine using FDG PET and gene expression
| Project/Area Number |
26461857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
KUDO Takashi 長崎大学, 原爆後障害医療研究所, 教授 (20330300)
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| Co-Investigator(Kenkyū-buntansha) |
福岡 順也 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00324575)
上谷 雅孝 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40176582)
井原 誠 長崎大学, 原爆後障害医療研究所, 助教 (60175213)
七島 篤志 宮崎大学, 医学部, 教授 (60380838)
岡市 協生 長崎大学, 原爆後障害医療研究所, 准教授 (80124874)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 核医学 / 膵癌 / テーラーメイド医療 / FDG PET / 腫瘍浸潤 / p53 |
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| Outline of Final Research Achievements |
Using positron emission tomography (PET) with F-18 FDG (fluolodeoxyglucose), we challenged prediction of microscopic/functional change through comparison between quantitative measurement of tumor glucose metabolism and histological specimen of cancer. We studied patients with pancreatic cancer and clarified that there is significant relationship between microscopic parameters and quantitatively measured maximum tumor FDG uptake which is useful for determination of patient specific therapy and management of cancer. We also compared operative/in-operative patients and revealed that tumor evaluation of tumor volume influenced determination of operability. Our result suggest that FDG maximum uptake is more important for determination of operability in pancreatic cancer. We also clarified that genetic variation of p53 in cancer cell influences FDG uptake.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Pediatric computed tomography practice in Japanese university hospitals from 2008-2010: did it differ from German practice?2017
Author(s)
Yoshida K, Krille L, Dreger S, Hoenig L, Merzenich H, Yasui K, Kumagai A, Ohtsuru A, Uetani M, Mildenberger P, Takamura N, Yamashita S, Zeeb H, Kudo T.
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Journal Title
Radiation Research
Volume: 58
Issue: 1
Pages: 135-141
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical Significance of Serum p53 Antibody in the Early Detection and Poor Prognosis of Gastric Cancer.2017
Author(s)
Kunizaki M, Fukuda A, Wakata K, Tominaga T, Nonaka T, Miyazaki T, Matsumoto K, Sumida Y, Hidaka S, Yasutake T, Sawai T, Hamamoto R, Nanashima A, Nagayasu T.
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Journal Title
Anticancer Research
Volume: 37
Issue: 4
Pages: 1979-1984
DOI
Related Report
Peer Reviewed
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[Journal Article] Diagnosis of complex renal cystic masses and solid renal lesions using PET imaging: comparison of 11C-acetate and 18F-FDG PET imaging.2014
Author(s)
Oyama N, Ito H, Takahara N, Miwa Y, Akino H, Kudo T, Okazawa H, Fujibayashi Y, Komatsu K, Tsukahara K, Yokoyama O.
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Journal Title
Clin Nucl Med
Volume: 39
Issue: 3
Pages: 208-214
DOI
Related Report
Peer Reviewed
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[Presentation] Pediatric CT practice. Comparison between three hospitals in Japan and Germany2014
Author(s)
Takashi Kudo, Koji Yoshida, Lucian Krille, Steffen Mueller, Lars Hoenig, Hiltrud Merzenich, Masataka Uetani, Peter Mildenberger, Noboru Takamura, Shunich Yamashita, Hajo Zeeb
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe (Kobe Convention Center / Kobe Portopia Hotel)
Year and Date
2014-09-24 – 2014-09-28
Related Report
