Bioadaptive small covered stent using nano-caobon compsit and electrispinning

Research Project

Project/Area Number	26461862
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Oita University
Principal Investigator	HONGO NORIO 大分大学, 医学部, 助教 (70419646)
Co-Investigator(Kenkyū-buntansha)	豊田昌宏大分大学, 工学部, 教授 (00290742)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords	カバードステント / ナノカーボン / 動脈瘤 / 電界紡糸 / エレクトロスピニング / 生体適合性 / ステントグラフト / 膨張化炭素繊維 / ナノファイバー / 末梢血管用ステント / 血管内治療
Outline of Final Research Achievements	The aim of this study is to develop bio-adaptable covered stent and the details of this study are followings. We generated nano-carbon composite sheets from toughened polyurethane on electrospinning technique and we confirmed increased durability of the material. We succeeded in integral modeling of the covered stent using electrospinning technique. High bio-adaptability with neo-intimal formation of the inner lumen was observed on the chronic in vivo test of the covered stent. Side branch preservation through the covered stent is also confirmed