| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We clarified that factors related to the glutamate metabolism pathway lead to radiation sensitivity enhancement among medium components in the cell culture environment. Enhancement of radiosennsitivity by conditioned mediuum from culturing for 4 days could be confirmed in several types of human cancer cell lines, but because it was not seen in normal cells, it is highly likely to be cancer cell specific. As a mechanism, it was confirmed that the reduction of glutathione synthesis by the suppression of the glutamate pathway, and the increase of the oxidative stress accordingly. This result suggests that the glutamate metabolic pathway may be an effective target for cancer killing effects in radiotherapy.
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