| Project/Area Number |
26461927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古村 眞 埼玉医科大学, 医学部, 教授 (10422289)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
佐竹 亮介 埼玉医科大学, 医学部, 講師 (70597525)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 気管軟骨移植 / 分子生物学的キメラ / 気管軟骨移植手技 / 細胞分離・培養 / 軟骨細胞 / 胆管上皮 / 同系移植 / 胆管上皮細胞 |
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| Outline of Final Research Achievements |
To induce immuno-tolerance, we tried to induce MHC Class 1 and 2 expression on recipient tissue to be molecular chimeric state. We chose tracheal cartilage and bile duct epithelia and succeeded in harvesting them and isolation and tissue transplantation, but we failed in induction of MHC Class 1 and 2. Therefore, we did not get any expected results.
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