Establishment of estrogen receptor positive breast cancer risk model consisting of genetic polymorphisms and serum biomarkers
| Project/Area Number |
26461955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
遠藤 友美 名古屋市立大学, 大学院医学研究科, 講師 (20566228)
遠山 竜也 名古屋市立大学, 大学院医学研究科, 教授 (30315882)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エストロゲンレセプター陽性乳癌 / 一塩基多型 / 血清バイオマーカー / 遺伝子多型 / リスクモデル / 乳癌易罹患性 |
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| Outline of Final Research Achievements |
We tried to reveal the occurring mechanism of estrogen receptor positive breast cancer that grow by female endocrine hormone. We pointed single nucleotide polymorphism (SNP), which are recently reported correlation with many kind of disease. We reported that TNRC9 rs3803662 affects to mammographic density, and CYP17A1 rs743572 affects to serum testosterone concentration, resulting in breast cancer high risk.
We may reduce estrogen receptor positive breast cancer occurrence by revealing these mechanisms.
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Report
(4 results)
Research Products
(3 results)
