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Establishment of estrogen receptor positive breast cancer risk model consisting of genetic polymorphisms and serum biomarkers

Research Project

Project/Area Number 26461955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNagoya City University

Principal Investigator

YOSHIMOTO Nobuyasu  名古屋市立大学, 大学院医学研究科, 研究員 (10551244)

Co-Investigator(Kenkyū-buntansha) 遠藤 友美  名古屋市立大学, 大学院医学研究科, 講師 (20566228)
遠山 竜也  名古屋市立大学, 大学院医学研究科, 教授 (30315882)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsエストロゲンレセプター陽性乳癌 / 一塩基多型 / 血清バイオマーカー / 遺伝子多型 / リスクモデル / 乳癌易罹患性
Outline of Final Research Achievements

We tried to reveal the occurring mechanism of estrogen receptor positive breast cancer that grow by female endocrine hormone. We pointed single nucleotide polymorphism (SNP), which are recently reported correlation with many kind of disease. We reported that TNRC9 rs3803662 affects to mammographic density, and CYP17A1 rs743572 affects to serum testosterone concentration, resulting in breast cancer high risk.
We may reduce estrogen receptor positive breast cancer occurrence by revealing these mechanisms.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] 疫学因子・血清因子からなるマンモグラフィ濃度予測モデルの改良~統 計学的手法を用いた重要因子の同定~2016

    • Author(s)
      吉本信保
    • Organizer
      第24回日本乳癌学会学術集会
    • Place of Presentation
      東京ビックサイト(東京都江東区)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遺伝因子を考慮したエストロゲンレセプター陽性乳癌罹患高リスク群同定への個別化アプローチ2016

    • Author(s)
      吉本信保
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] TNRC9 rs3803662がマンモグラフィ濃度とエストロゲンレセプター陽性乳癌罹患リスクに与える影響2015

    • Author(s)
      吉本信保
    • Organizer
      第23回日本乳癌学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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