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Elucidation of the mechanism of drug resistance in colorectal cancer by p62-Keap 1-Nrf2 pathway

Research Project

Project/Area Number 26462006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNiigata University

Principal Investigator

KAMEYAMA Hitoshi  新潟大学, 医歯学系, 准教授 (40626420)

Co-Investigator(Kenkyū-buntansha) 若井 俊文  新潟大学, 医歯学系, 教授 (50372470)
味岡 洋一  新潟大学, 医歯学系, 教授 (80222610)
西條 康夫  新潟大学, 医歯学系, 教授 (10270828)
松田 康伸  新潟大学, 医歯学系, 准教授 (40334669)
小山 諭  新潟大学, 医歯学系, 教授 (10323966)
廣瀬 雄己  新潟大学, 医歯学総合病院, 医員 (10737365)
小杉 伸一  新潟大学, 医歯学総合病院, 特任教授 (90401736)
小林 隆  新潟大学, 医歯学総合病院, 講師 (40464010)
永橋 昌幸  新潟大学, 医歯学総合病院, 講師 (30743918)
Co-Investigator(Renkei-kenkyūsha) KOMATSU Masaaki  新潟大学, 医歯学系, 教授 (90356254)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大腸癌 / 抗癌剤耐性 / NQO1 / KRAS / Nrf2 / Keap1 / p62
Outline of Final Research Achievements

p62-Keap1-Nrf2 pathway induce the antioxidants like NQO1. In cancer cells, NQO1 confers resistance against anticancer agents. The aim of this study was to evaluate the association between NQO1 expression and prognosis in patients with advanced colorectal cancer (CRC). Among the patients with KRAS wild CRC, NQO1-negative patients showed significantly better disease control rate than NQO1-positive patients. Moreover, NQO1-negative patients had longer progression-free survival and overall survival than NQO1-positive patients. NQO1 expression in the tumor may be a predictor of therapeutic efficacy and prognosis in patients with KRAS wild advanced CRC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Clinical significance of NQO1 expression in patients with advanced KRAS wild colorectal cancer2017

    • Author(s)
      Hitoshi Kameyama, Yuki Hirose, Yasunobu Matsuda, Masayuki Nagahashi, Hiroshi Ichikawa, You Sato, Saki Yamada, Shinnosuke Hotta, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 切除不能・再発大腸癌における NAD(P)H: quinone oxidoreductase 1発現の臨床的意義2015

    • Author(s)
      佐藤 洋
    • Journal Title

      新潟医学会雑誌

      Volume: 129 Pages: 300-308

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 大腸癌化学療法におけるNQO1発現解析の意義2016

    • Author(s)
      亀山仁史,廣瀬雄己,島田能史,八木亮磨,田島陽介,岡村拓磨,中野雅人,市川 寛,永橋昌幸,坂田 純,小林 隆,若井俊文
    • Organizer
      JDDW 2016
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clinical significance of NQO1 expression in patients with KRAS wild-type unresectable colorectal cancer2016

    • Author(s)
      Hitoshi Kameyama, Yuki Hirose, Yoshifumi Shimada, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Masayuki Nagahashi, Takashi Kobayashi, Toshifumi Wakai
    • Organizer
      IASGO 2016
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NQO1 EXPRESSION HAS PROGNOSTIC SIGNIFICANCE IN KRAS-WILD UNRESECTABLE COLORECTAL CANCER2015

    • Author(s)
      Y. Hirose, H. Kameyama, T. Ohashi, K. Takizawa, M. Nagahashi, T. Kobayashi, J. Sakata, T. Wakai
    • Organizer
      46th World Congress of Surgery
    • Place of Presentation
      Bangkok
    • Year and Date
      2015-08-23 – 2015-08-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 進行再発大腸癌におけるNQO1発現の臨床的意義2014

    • Author(s)
      亀山仁史,廣瀬雄己,佐藤 洋,山田沙季,阿部 馨,庭野稔之,岩城孝和,八木亮磨,田島陽介,中野麻恵,中野雅人,島田能史,坂田 純,小林 隆,皆川昌広,小杉伸一,小山 諭,若井俊文
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-16 – 2014-04-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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