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Role of Surtuins in the carcinogenesis of colitis-associated cancer

Research Project

Project/Area Number 26462009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Kurachi Kiyotaka  浜松医科大学, 医学部, 助教 (20397384)

Co-Investigator(Kenkyū-buntansha) 今野 弘之  浜松医科大学, 医学部, 学長 (00138033)
山本 真義  浜松医科大学, 医学部附属病院, 診療助教 (70397420)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords炎症性腸疾患 / 発癌 / 低酸素 / Sirtuin
Outline of Final Research Achievements

First, we assessed the Sirtuins expression level and acetylation level of its downstream target proteins in colorectal cancer cell lines after cytokine stimulation. However, these levels were not detected. In CAC mouse model, we analyzed the Sirtuins expression levels. However, the Sirtuins expression levels were not significantly different. Next, we analyzed the Sirtuins expression levels in surgically resected human CAC samples by immunohistochemistry. We found that the expression level of Sirt-1 and -7 were significantly suppressed in CAC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2014

All Presentation (3 results)

  • [Presentation] Colitis Associated CancerにおけるSirtuinの関与2014

    • Author(s)
      山本真義
    • Organizer
      第25回日本消化器癌発生学会総会
    • Place of Presentation
      ホテル日航福岡
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Colitis Associated Cancer (CAC) におけるSirt7の発現解析2014

    • Author(s)
      山本真義
    • Organizer
      第22回日本消化器関連学会週間
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Colitis Associated Cancer (CAC) の発癌過程におけるSirtuinの関与2014

    • Author(s)
      山本真義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山総合体育館
    • Year and Date
      2014-07-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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