| Project/Area Number |
26462009
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
山本 真義 浜松医科大学, 医学部附属病院, 診療助教 (70397420)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 炎症性腸疾患 / 発癌 / 低酸素 / Sirtuin |
|---|
| Outline of Final Research Achievements |
First, we assessed the Sirtuins expression level and acetylation level of its downstream target proteins in colorectal cancer cell lines after cytokine stimulation. However, these levels were not detected. In CAC mouse model, we analyzed the Sirtuins expression levels. However, the Sirtuins expression levels were not significantly different. Next, we analyzed the Sirtuins expression levels in surgically resected human CAC samples by immunohistochemistry. We found that the expression level of Sirt-1 and -7 were significantly suppressed in CAC.
|
