DNA methylation biomarkers predict development of UC-associated colorectal neoplasia
| Project/Area Number |
26462011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
Toiyama Yuji 三重大学, 医学部附属病院, 講師 (00422824)
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| Co-Investigator(Kenkyū-buntansha) |
川村 幹雄 三重大学, 医学系研究科, リサーチアソシエイト (00722589)
井上 靖浩 三重大学, 医学部附属病院, 講師 (20324535)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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| Research Collaborator |
FUJIKAWA HIROYUKI 三重大学, 医学部附属病院, 助教 (40616091)
KONDO SATORU 三重大学, 医学部附属病院, 医員 (60763737)
HIRO JYUNICHIRO 三重大学, 医学部附属病院, 助教 (70444437)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | DNAメチル化 / マイクロRNA / 潰瘍性大腸炎 / 癌化 / microRNA / バイオマーカー |
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| Outline of Final Research Achievements |
Colitis-associated cancer (CAC) is higher among long-standing ulcerative colitis (UC) patients, such as that for whom surveillance colonoscopy is widely recommended. However, CAC is often difficult to detect endoscopically and histologically because of mucosal structure modifications by inflammation. Therefore, several molecular alterations may be promising as markers for identifying patients at high risk of developing CAC First, we investigated the feasibility of using the methylation status of several microRNAs, which have characteristic of both type C (methylated during carcinogenesis) and type A (methylated during aging) simultaneously as a promising biomarker in CAC. We next performed the analysis of these biomarkers from rectal biopsy specimen has robust predictive potential in identifying UC patients with CAC elsewhere in the colorectum. In addition, we confirmed the reproducibly by using a large cohort.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 潰瘍性大腸炎患者の大腸粘膜におけるmiR-137メチル化の臨床病理学的意義2016
Author(s)
問山 裕二, 奥川 喜永, 今岡 裕貴, 沖上 正人, 藤川 裕之, 三枝 晋, 廣 純一郎, 小林 美奈子, 大井 正貴, 荒木 俊光, 井上 靖浩, 毛利 靖彦, 楠 正人.
Organizer
日本大腸肛門病学会学会
Place of Presentation
三重県営サンアリーナ（三重県伊勢市）
Year and Date
2016-11-18
Related Report
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[Presentation] 散発性ならびに潰瘍性大腸炎関連癌におけるエピゲノム異常から見た発癌、予後に対するリスク診断法2015
Author(s)
Yuji Toiyama, Yoshinaga Okugawa, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
Organizer
日本消化器外科学会総会
Place of Presentation
アクトシティ浜松（静岡県・浜松市）
Year and Date
2015-07-15
Related Report
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[Presentation] 潰瘍性大腸炎癌化におけるmicroRNA-124、-137、-34b/cメチル化の意義2014
Author(s)
問山 裕二, Hur Keun, 沖上 正人, 川村 幹雄, 川本 文, 奥川 喜永, 廣 純一郎, 荒木 俊光, 田中 光司, 井上 靖浩, 内田 恵一, 毛利 靖彦, 楠 正人, Boland Richard C., Goel Ajay
Organizer
日本癌治療学会
Place of Presentation
横浜 （パシフィコ横浜）
Year and Date
2014-08-28 – 2014-08-30
Related Report
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[Presentation] MicroRNA-124プロモーター領域メチル化の大腸癌バイオマーカーとしての可能性2014
Author(s)
問山 裕二, Hur Keun, 川村 幹雄, 川本 文, 奥川 喜永, 廣 純一郎, 田中 光司, 井上 靖浩, 永坂 岳志, 毛利 靖彦, 楠 正人, Boland Richard C., Goel Ajay
Organizer
日本外科学会
Place of Presentation
京都 （国立京都国際会館・グランドプリンスホテル京都）
Year and Date
2014-04-03 – 2014-04-05
Related Report
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