| Project/Area Number |
26462011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
Toiyama Yuji 三重大学, 医学部附属病院, 講師 (00422824)
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| Co-Investigator(Kenkyū-buntansha) |
川村 幹雄 三重大学, 医学系研究科, リサーチアソシエイト (00722589)
井上 靖浩 三重大学, 医学部附属病院, 講師 (20324535)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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| Research Collaborator |
FUJIKAWA HIROYUKI 三重大学, 医学部附属病院, 助教 (40616091)
KONDO SATORU 三重大学, 医学部附属病院, 医員 (60763737)
HIRO JYUNICHIRO 三重大学, 医学部附属病院, 助教 (70444437)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | DNAメチル化 / マイクロRNA / 潰瘍性大腸炎 / 癌化 / microRNA / バイオマーカー |
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| Outline of Final Research Achievements |
Colitis-associated cancer (CAC) is higher among long-standing ulcerative colitis (UC) patients, such as that for whom surveillance colonoscopy is widely recommended. However, CAC is often difficult to detect endoscopically and histologically because of mucosal structure modifications by inflammation. Therefore, several molecular alterations may be promising as markers for identifying patients at high risk of developing CAC First, we investigated the feasibility of using the methylation status of several microRNAs, which have characteristic of both type C (methylated during carcinogenesis) and type A (methylated during aging) simultaneously as a promising biomarker in CAC. We next performed the analysis of these biomarkers from rectal biopsy specimen has robust predictive potential in identifying UC patients with CAC elsewhere in the colorectum. In addition, we confirmed the reproducibly by using a large cohort.
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