examination of the colorectal cancer marker using metabolomics from saliva

• Project/Area Number: 26462027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: Katsumata kenji 東京医科大学, 医学部, 教授 (10214347)
• Co-Investigator(Kenkyū-buntansha): 石崎 哲央 東京医科大学, 医学部, 講師 (00424531) ; 砂村 眞琴 東京医科大学, 医学部, 兼任教授 (10201584) ; 杉本 昌弘 東京医科大学, 医学部, 教授 (30458963) ; 土田 明彦 東京医科大学, 医学部, 主任教授 (50207396) ; 久田 将之 東京医科大学, 医学部, 助教 (50385100) ; 粕谷 和彦 東京医科大学, 医学部, 兼任教授 (80307313)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 大腸腺腫 / 大腸癌 / 診断 / 唾液 / 尿 / メタボローム / 血清 / スクリーニング / 大腸腫瘍

Outline of Final Research Achievements

As for the analytical results of the salivary metabolome, the patients with colorectal cancer showed a significant difference to 15 kinds with a healthy subject. the polypous patients showed a significant difference to 18 kinds.Whereas a significant difference only for one kind was confirmed in the patients with polyps and cancer.We were very superior in sensitivity and specificity in patients with colorectal cancer, the patients with polyps, all when we paid our attention to N1-Acetylspermidin.After being a study for the purpose of the screening of the colon cancer and polyp and analyzing it for a healthy subject, as compared with former cancer alone more excellent detection power was obtained in AUC = 0.848.As a result, it is thought to be more likely to detect the presence of the early cancer and polyp which it may not detect by the fecal occult-blood testing under the present conditions to be guessed more

Research Products

• [Journal Article] Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers,Benign Disease,and Healthy Controls (2018)
  • Author(s): Tetsushi Nakajima kenji Katsumata Hiroshi Kuwabara Ryoko Soya Masanobu Enomoto Tetsuo Ishizaki Akihiko Tsuchida Masayo Mori Kana Hiwatari Tomoyoshi Soga Masaru Tomita Masashi Sugimoto
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Pages: 765778-765778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 唾液メタボロームを用いた大腸腫瘍の理小診断技術の確立 (2018)
  • Author(s): 桒原寛 杉本昌弘 和田貴宏 松土尊映 榎本正統 石崎哲央 永川裕一 勝又健次 土田明彦
  • Organizer: 第118回日本外科学会
• [Presentation] Salivary biomarker discovery for colon cancer using metabolomics (2018)
  • Author(s): Hiroshi Kuwabara Masahiro Sugimoto Takahiro Wada Takaaki Matsudo Masanobu Enomoto Tetsuo Ishizaki kenji Katsumata Akihiko Tsuchida
  • Organizer: International association of surgeons,gastroenterologist and oncologist
  • Int'l Joint Research
• [Presentation] 唾液メタボロームを用いた大腸腫瘍の理小診断技術の確立 (2017)
  • Author(s): 桒原寛 杉本昌弘 松土尊映 新後閑正敏 榎本正統 河北英明 石崎哲央 久田将之 勝又健次 土田明彦
  • Organizer: 第87回大腸癌研究会
• [Presentation] Examination of the colorectal cancer marker using metabolomics from urine analysis (2017)
  • Author(s): Tetsushi Nakajima Kenji Katsumata Masahiro Sugimoto Akihiko Tuchida
  • Organizer: The international college of surgeons
  • Place of Presentation: Tokyo Japan