Development of anti-cancer therapy by control of transposon

Research Project

Project/Area Number	26462028
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Tokyo Women's Medical University
Principal Investigator	Kawakami Kazuyuki 東京女子医科大学, 医学部, 准教授 (00293358)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	レトロポゾン / 抗がん剤 / 大腸がん / LINE-1 / 大腸癌
Outline of Final Research Achievements	Growth of colorectal cancer cell lines are inhibited by suppression of LINE-1. LINE-1 was located in stress granule, suggesting that microRNA expression is involved in the mechanism by which knockdown of LINE-1 inhibit cancer growth. However, further experiment shows no evidence that the microRNA expression is involved in the association between knockdown of LINE-1 and inhibiting cancer growth. Further experiment is needed for controlling LINE-1 ORF1 expression as a molecular target of cancer therapy.

Report

(4 results)