Development of artificial liver support system from view of liver immunity and liver regeneration

• Project/Area Number: 26462040
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Yamanashi
• Principal Investigator: FUJII Hideki 山梨大学, その他部局等, 理事 (30181316)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 人工肝補助装置 / 肝クッパー細胞 / 肝細胞癌 / 肝炎 / 肝再生 / IL-17A / M-CSF / CLEC-2 / 人工肝臓補助システム / VEGF / 肝類洞 / 人工肝臓補助装置 / 肝マクロファージ / interleukin 17A / 人口肝臓補助装置 / マクロファージ刺激因子 / 血管内皮増殖因子 / アポトーシス

Outline of Final Research Achievements

It is very important to clarify the mechanism of the liver diseases for considering an indication of artificial liver support system to the liver diseases such as HCC, hepatitis and liver regeneration. As HCC, IL-17A plays a pivotal role in chemically induced hepatic carcinogenesis, which is most likely through inflammation-initiated oxidative DNA damage and cell proliferation. And M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic MΦ. As hepatitis, IL-17A is a key regulator in hepatic injury caused by neutrophil-induced inflammatory responses after LPS/GalN injection. As liver regeneration C-type lectin receptor-2 (CLEC-2) accelerates the liver regeneration after hepatectomy.

Research Products

• [Journal Article] The platelet-activating receptor C-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice. (2017)
  • Author(s): Kono H, Fujii H, Suzuki-Inoue K, Inoue O, Furuya S, Hirayama K, Akazawa Y, Nakata Y, Sun C, Tsukiji N, Shirai T, Ozaki Y
  • Journal Title: Journal of thrombosis and haemostasis Volume: 印刷中 Issue: 5 Pages: 1-11
  • DOI: 10.1111/jth.13672
  • Peer Reviewed
• [Journal Article] Interleukin-17A Plays a Pivotal Role in Chemically Induced Hepatocellular Carcinoma in Mice. (2016)
  • Author(s): Sun C, Kono H, Furuya S, Hara M, Hirayama K, Akazawa Y, Nakata Y, Fujii H.
  • Journal Title: Dig Dis Sci. Volume: 61 Issue: 2 Pages: 474-488
  • DOI: 10.1007/s10620-015-3888-1
  • Peer Reviewed
• [Journal Article] Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma. (2016)
  • Author(s): Kono H1, Fujii H1, Furuya S1, Hara M1, Hirayama K1, Akazawa Y1, Nakata Y1, Tsuchiya M1, Hosomura N1, Sun C1.
  • Journal Title: World J Gastroenterol. Volume: 22 Issue: 39 Pages: 8779-8789
  • DOI: 10.3748/wjg.v22.i39.8779
  • Peer Reviewed
• [Journal Article] Comparison of the diagnostic accuracies of magnetic resonance elastography and transient elastography for hepatic fibrosis. (2015)
  • Author(s): Ichikawa S, Motosugi U, Morisaka H, Sano K, Ichikawa T, Tatsumi A, Enomoto N, Matsuda M, Fujii H, Onishi H.
  • Journal Title: Magn Reson Imaging. Volume: 33 Issue: 1 Pages: 26-30
  • DOI: 10.1016/j.mri.2014.10.003
  • Peer Reviewed
• [Journal Article] Was Hypervascular Hepatocellular Carcinoma Visible on Previous Gadoxetic Acid-Enhanced Magnetic Resonance Images? (2015)
  • Author(s): Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H.
  • Journal Title: Liver Cancer Volume: 4 Issue: 3 Pages: 154-162
  • DOI: 10.1159/000367736
  • Peer Reviewed
• [Journal Article] Interleukin 17A plays a role in lipopolysaccharide/D-galactosamine-induced fulminant hepatic injury in mice. (2015)
  • Author(s): Furuya S, Kono H, Hara M, Hirayama K, Sun C, Fujii H
  • Journal Title: J Surg Res Volume: 199 Issue: 2 Pages: 487-493
  • DOI: 10.1016/j.jss.2015.05.060
  • Peer Reviewed
• [Journal Article] Macrophage colony-stimulating factor plays a pivotal role in chemically induced hepatocellular carcinoma in mice. (2013)
  • Author(s): Hara M
  • Journal Title: Hepatol Res Volume: Epub ahead of print Issue: 7 Pages: 798-811
  • DOI: 10.1111/hepr.12174
  • Peer Reviewed
• [Remarks] 山梨大学 研究者総覧
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_Index.Main?