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Clinicopatholigcai and molecula biological analysis of carcinogenesis induced by chemicals

Research Project

Project/Area Number 26462048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University

Principal Investigator

Kubo Shoji  大阪市立大学, 大学院医学研究科, 准教授 (80221224)

Co-Investigator(Kenkyū-buntansha) 竹村 茂一  大阪市立大学, 大学院医学研究科, 講師 (00322363)
中沼 安二  金沢大学, 医学系, 協力研究員 (10115256)
西尾 和人  近畿大学, 医学部, 教授 (10208134)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords職業性胆管癌 / 1,2-ジクロロプロパン / ジクロロメタン / 肝内胆管癌 / 前癌病変 / 遺伝子異常 / 多段階発育 / 前癌病変DNA傷害 / 多段階発癌 / DNA傷害
Outline of Final Research Achievements

The analysis of occupational cholangiocarcinoma showed that young age, high gamma-GTP level, regional dilation of intrahepatic bile duct, the presence of biliary intraepithelial neoplasia(BilIN)and intraductal neoplasm of the bile duct(IPNB)as well as invasive cholangiocarcinoma are characteristics of the carcinoma. The molecular biological studies showed that such lesions had hypermutation of DNA. These results indicate that some chemicals induced DNA injury, inducing premalignant lesions such as BilIN and IPNB, eventually developing invasive cholangiocarcinoma in the occupational cholangiocarcinoma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (49 results)

All 2017 2016 2015 2014

All Journal Article (28 results) (of which Peer Reviewed: 23 results,  Acknowledgement Compliant: 5 results,  Open Access: 12 results) Presentation (21 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] MR imaging and MR cholangiopancreatography of cholangiocarcinoma developing in printing company workers.2017

    • Author(s)
      Koyama K, Kubo S, Ueki A, Shimono T, Takemura S, Tanaka S, Kinoshita M, Hamano G, Miki Y.
    • Journal Title

      Jpn J Radiol.

      Volume: 印刷中 Issue: 5 Pages: 233-241

    • DOI

      10.1007/s11604-017-0626-y

    • NAID

      50012595356

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes after resection of occupational cholangiocarcinoma2016

    • Author(s)
      Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Hamano G, et al.
    • Journal Title

      Journal of Hepato-Biliary Pancreatic Sciences

      Volume: 23 Issue: 9 Pages: 556-564

    • DOI

      10.1002/jhbp.373

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The PD-1/PD-L1 may be aberrantly activated in occupational cholangiocarcinoma2016

    • Author(s)
      Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S
    • Journal Title

      Pathology International

      Volume: 67 Issue: 3 Pages: 163-170

    • DOI

      10.1111/pin.12511

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 職業性胆管癌の臨床的特徴2016

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、西岡孝芳、木下正彦、濱野玄弥、伊藤得路、中沼安二、圓藤吟史
    • Journal Title

      日本職業・災害医学会会誌

      Volume: 64 Pages: 1-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝内胆管癌の疫学的動向と危険因子2016

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、木下正彦、濱野玄弥、伊藤得路、青田尚哲、江田将樹、上西崇弘
    • Journal Title

      外科

      Volume: 78 Pages: 115-121

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents2016

    • Author(s)
      Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S.
    • Journal Title

      Surg Today

      Volume: 46 Issue: 6 Pages: 705-712

    • DOI

      10.1007/s00595-015-1229-9

    • NAID

      120006586208

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020497

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathological spectrum of bile duct lesions from chronic bile duct injury to invasice cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma.2016

    • Author(s)
      Kinoshita M, Kubo S, Nakanuma Y, Sato Y, Takemura S, Tanaka S, Hamano G, Ito T, Terajima H, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Sugawara Y, Yamamoto T, Abue M, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Shirabe K, Shibata T.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 23 Issue: 2 Pages: 92-101

    • DOI

      10.1002/jhbp.305

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents.2016

    • Author(s)
      Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S
    • Journal Title

      Surgery Today

      Volume: 印刷中

    • NAID

      120006586208

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of clinicopathological characteristics between patients with occupational and non-occupational intrahepatic cholangiocarcinoma.2016

    • Author(s)
      Hamano G, Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Ito T, Yamamoto T, Wakasa K, Shibata T.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 肝内胆管癌の疫学的動向とリスク因子2016

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、木下正彦、濱野玄弥、伊藤得路、青田哲尚、江田将樹、上西崇弘.
    • Journal Title

      外科

      Volume: 78 Pages: 115-121

    • Related Report
      2015 Research-status Report
  • [Journal Article] Comparison of Clinical Characteristics between Occupational and Sporadic Young-Onset Cholangiocarcinoma.2015

    • Author(s)
      Kaneko R, Kubo S, Sato Y.
    • Journal Title

      Asian Pac J Cancer Prev.

      Volume: 16 Issue: 16 Pages: 7195-7200

    • DOI

      10.7314/apjcp.2015.16.16.7195

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe acute hepatitis in a printing company worker: A case study2015

    • Author(s)
      Kubo S, Matsuzaki K, Seki T, Ohsawa M, Kumagai S, Endo G.
    • Journal Title

      Journal of Occupational Health

      Volume: 57 Issue: 1 Pages: 87-90

    • DOI

      10.1539/joh.14-0122-CS

    • NAID

      130004713078

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemical exposure levels in printing and coating workers with cholangiocarcinoma (third report)2015

    • Author(s)
      Yamada K, Kumagai S, Kubo S, Endo G.
    • Journal Title

      Journal of Occupational Health

      Volume: 57 Issue: 6 Pages: 565-571

    • DOI

      10.1539/joh.15-0170-OA

    • NAID

      130005116263

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 職業性胆管癌症例の臨床的特徴2015

    • Author(s)
      久保正二、竹村茂一、田中肖吾、木下正彦、濱野玄弥、伊藤得路、青田哲尚、江田将樹、中沼安二.
    • Journal Title

      産業医学レビュー

      Volume: 28 Pages: 139-146

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 職業性胆管癌の病態とその特徴2015

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、木下正彦、濱野玄弥、伊藤得路、青田哲尚、江田将樹、佐藤保則、中沼安二.
    • Journal Title

      肝胆膵

      Volume: 71 Pages: 877-885

    • Related Report
      2015 Research-status Report
  • [Journal Article] 職業性胆管癌の臨床的特徴2015

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、西岡孝芳、木下正彦、濱野玄弥、伊藤得路、中沼安二、圓藤吟史.
    • Journal Title

      日本職業・災害医学会会誌

      Volume: 64 Pages: 1-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腫瘍性コランギオパチー(胆道腫瘍) 職業性胆管癌の病態とその特徴2015

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二、木下正彦、濱野玄弥、伊藤得路、青田哲尚、江田将樹、佐藤保則、中沼 安二.
    • Journal Title

      肝胆膵

      Volume: 71 Pages: 877-885

    • Related Report
      2015 Research-status Report
  • [Journal Article] 印刷業職業性胆管癌に対する化学放射線療法と根治的肝切除の経験2015

    • Author(s)
      中川 圭、片寄 友、石田和之、林 洋毅、森川孝則、吉田 寛、元井冬彦、内藤 剛、久保正二、海野倫明.
    • Journal Title

      日本消化器病学会雑誌

      Volume: 112 Pages: 1341-1347

    • NAID

      130005084740

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 印刷業勤務を背景に発症した肝内胆管癌の1例2015

    • Author(s)
      木村光一、調 憲、久保正二、伊藤心二、播本憲史、山下洋市、吉住朋晴、相島慎一、小田義直、前原喜彦.
    • Journal Title

      胆道

      Volume: 29 Pages: 972-977

    • NAID

      130005119509

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan.2014

    • Author(s)
      Kubo S, Nakanuma Y, Takemura S, Sakata C, Urata Y, Nozawa A, Nishioka T, Kinoshita M, Hamano G, Terajima H, Tachiyama G, Matsumura Y, Yamada T, Tanaka H, Nakamori S, Arimoto A, Kawada N, Fujikawa M, Fujishima H, Sugawara Y, Tanaka S, Toyokawa H, Kuwae Y, Ohsawa M, Uehara S, Sato KK, Hayashi T, Endo G.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 21 Issue: 7 Pages: 479-488

    • DOI

      10.1002/jhbp.86

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma2014

    • Author(s)
      KuboS, et al
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 21 Pages: 809-817

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan2014

    • Author(s)
      Sato Y, Kubo S, et al.
    • Journal Title

      International Journal of Clinical and Experimental Pathology

      Volume: 7 Pages: 4745-4754

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in laboratory test results and diagnostic imaging presentation before the detection of occupational cholangiocarcinoma2014

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Journal of Occupational Health

      Volume: 56 Pages: 317-322

    • NAID

      130004447660

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cholangiocarcinomain a middle-aged patient working at a printing company2014

    • Author(s)
      Tanaka S, Kubo S, et al.
    • Journal Title

      Osaka City Medical Journal

      Volume: 60 Pages: 39-44

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 印刷労働者における胆管癌多発事例:新たな職業癌2014

    • Author(s)
      久保正二, 他
    • Journal Title

      日本消化器病学会雑誌

      Volume: 111 Pages: 500-509

    • NAID

      130003392012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 印刷労働者に多発した胆管癌2014

    • Author(s)
      久保正二、他
    • Journal Title

      胆道

      Volume: 28 Pages: 763-771

    • NAID

      130004838926

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 職業性暴露(印刷業)による胆管・胆道癌の特徴:病理所見および発癌メカニズムを中心に2014

    • Author(s)
      中沼安二、久保正二、他
    • Journal Title

      肝胆膵

      Volume: 69 Pages: 1079-1085

    • Related Report
      2014 Research-status Report
  • [Journal Article] 印刷会社勤務歴を有する肝内胆管癌の1例2014

    • Author(s)
      虻江 誠、久保正二、他
    • Journal Title

      胆道

      Volume: 28 Pages: 696-702

    • NAID

      130004838917

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 職業性胆管癌の手術成績2016

    • Author(s)
      木下正彦,竹村茂一,田中肖吾,新川寛二,濱野玄弥,伊藤得路,江田将樹,青田尚哲,久保正二
    • Organizer
      第14回日本消化器外科学会大会
    • Place of Presentation
      神戸交際展示場(兵庫県神戸市)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 職業性肝内胆管癌と非職業性肝内胆管癌との臨床病理学的比較2016

    • Author(s)
      濱野玄弥,竹村茂一,田中肖吾,新川寛二,木下正彦,伊藤得路,青田尚哲,江田将樹,山本隆嗣,久保正二
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of cholangiocarcinoma in a printing company employee: Occupational cholangiocarcinoma2016

    • Author(s)
      Kubo S, Takemura S, Tanaka S, Kinoshita M, Hamano G, Nakanuma Y, Sato Y, Mimaki S, Tsuchihara K
    • Organizer
      The 7th Asia-Pacific Primary Liver Cancer Expert Meeting
    • Place of Presentation
      Hong Kong (China)
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 職業性胆管癌の臨床と対策.2016

    • Author(s)
      久保正二
    • Organizer
      第52回日本肝癌研究会
    • Place of Presentation
      虎の門ヒルズフォーラム(東京都港区)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 当科における職業性胆管癌切除症例の病理学的検討2015

    • Author(s)
      木下正彦,中沼安二,竹村茂一,佐藤保則,田中肖吾,新川寛二,西岡孝芳,濱野玄弥,伊藤得路,青田尚哲,江田将樹,久保正二
    • Organizer
      第13回日本消化器外科学会大会
    • Place of Presentation
      高野輪プリンスホテル(東京都)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 印刷業従業者胆管癌のゲノム変異より明らかとなった変異原物質の特徴2015

    • Author(s)
      三牧幸代,戸塚ゆ加里,落合淳志,久保正二,中森正二,中釜 斉,江角浩安,土原一哉
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 職業性胆管癌の病態と対策2015

    • Author(s)
      久保正二
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティー浜松(静岡県浜松市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 肝内胆管癌の治療成績と戦略2015

    • Author(s)
      久保正二,上西崇弘,竹村茂一
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本ホテルキャッスル(熊本県熊本市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] これまでの職業性胆管癌症例の検討-大阪での17例と新規労災認定9例の比較-2015

    • Author(s)
      木下正彦,中沼安二,竹村茂一,田中肖吾,新川寛二,西岡孝芳,濱野玄弥,伊藤得路,江田将樹,久保正二
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Comparison of clinicopathological characteristics between in the patients with occupational and non-occupational intrahepatic cholangiocarcinoma2015

    • Author(s)
      Hamano G,Kubo S, et al.
    • Organizer
      The 2nd Kansai-Yeungnam HBP Surgenos Joint Meeting 2015
    • Place of Presentation
      Wakayama Medical College [和歌山県、和歌山市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Radiological and pathological characteristics in occupational cholangiocarcinoma developing among young workers at a printing company in Japan2015

    • Author(s)
      Kinoshita M,Kubo S, et al.
    • Organizer
      The 2nd Kansai-Yeungnam HBP Surgenos Joint Meeting 2015
    • Place of Presentation
      Wakayama Medical Colledge
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 職業性胆管癌の臨床的特徴2014

    • Author(s)
      久保正二、他
    • Organizer
      第62回日本職業・災害医学会学術大会
    • Place of Presentation
      神戸国際会議場(兵庫県 神戸市)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 印刷工胆管癌の全エクソンシークエンス解析2014

    • Author(s)
      三牧幸代、久保正二、他
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 印刷労働者関連胆管癌症例における病理学的特徴2014

    • Author(s)
      木下正彦、久保正二、他
    • Organizer
      第50回日本胆道学会学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Outcomes of treatment intrahepatic cholangiocarcinoma among young workers at a printing company2014

    • Author(s)
      Kinoshita M, Kubo S, et al.
    • Organizer
      Daegu-Kansai HBP Surgeons Joint Meeting 2014
    • Place of Presentation
      YongNang University (YongNang 韓国)
    • Year and Date
      2014-08-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 印刷労働者関連胆管癌と他の胆管癌の臨床病理学的比較2014

    • Author(s)
      濱野玄弥、久保正二、他
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山市民文化センター(福島県 郡山市)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 印刷労働者関連胆管癌症例における画像所見および病理組織像の検討2014

    • Author(s)
      木下正彦、久保正二、他
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山市民文化センター(福島県 郡山市)
    • Year and Date
      2014-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 若年者胆道癌の発症要因に関する研究2014

    • Author(s)
      吉田 寛、久保正二、他
    • Organizer
      第26回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      和歌山県民文化会館(和歌山県 和歌山市)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 胆道癌とその前癌病変におけるDNA損傷に関する病理的検討2014

    • Author(s)
      佐藤保則、久保正二、他
    • Organizer
      第50回日本肝癌研究会
    • Place of Presentation
      京都国際会館(京都府 京都市)
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] オフセット校正印刷会社関連胆管癌切除例の病理組織学的検討2014

    • Author(s)
      浦田順久、久保正二、他
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館(京都府 京都市)
    • Year and Date
      2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 印刷労働者関連胆管癌症例におけるFDG-PET像2014

    • Author(s)
      木下正彦、久保正二、他
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館(京都府 京都市)
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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