Clinicopatholigcai and molecula biological analysis of carcinogenesis induced by chemicals
Project/Area Number |
26462048
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Osaka City University |
Principal Investigator |
Kubo Shoji 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
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Co-Investigator(Kenkyū-buntansha) |
竹村 茂一 大阪市立大学, 大学院医学研究科, 講師 (00322363)
中沼 安二 金沢大学, 医学系, 協力研究員 (10115256)
西尾 和人 近畿大学, 医学部, 教授 (10208134)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 職業性胆管癌 / 1,2-ジクロロプロパン / ジクロロメタン / 肝内胆管癌 / 前癌病変 / 遺伝子異常 / 多段階発育 / 前癌病変DNA傷害 / 多段階発癌 / DNA傷害 |
Outline of Final Research Achievements |
The analysis of occupational cholangiocarcinoma showed that young age, high gamma-GTP level, regional dilation of intrahepatic bile duct, the presence of biliary intraepithelial neoplasia(BilIN)and intraductal neoplasm of the bile duct(IPNB)as well as invasive cholangiocarcinoma are characteristics of the carcinoma. The molecular biological studies showed that such lesions had hypermutation of DNA. These results indicate that some chemicals induced DNA injury, inducing premalignant lesions such as BilIN and IPNB, eventually developing invasive cholangiocarcinoma in the occupational cholangiocarcinoma.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] The PD-1/PD-L1 may be aberrantly activated in occupational cholangiocarcinoma2016
Author(s)
Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S
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Journal Title
Pathology International
Volume: 67
Issue: 3
Pages: 163-170
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents.2016
Author(s)
Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S.
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Journal Title
Surg Today
Volume: 46
Issue: 6
Pages: 705-712
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathological spectrum of bile duct lesions from chronic bile duct injury to invasice cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma.2016
Author(s)
Kinoshita M, Kubo S, Nakanuma Y, Sato Y, Takemura S, Tanaka S, Hamano G, Ito T, Terajima H, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Sugawara Y, Yamamoto T, Abue M, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Shirabe K, Shibata T.
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 23
Issue: 2
Pages: 92-101
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents.2016
Author(s)
Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S
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Journal Title
Surgery Today
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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[Journal Article] Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan.2014
Author(s)
Kubo S, Nakanuma Y, Takemura S, Sakata C, Urata Y, Nozawa A, Nishioka T, Kinoshita M, Hamano G, Terajima H, Tachiyama G, Matsumura Y, Yamada T, Tanaka H, Nakamori S, Arimoto A, Kawada N, Fujikawa M, Fujishima H, Sugawara Y, Tanaka S, Toyokawa H, Kuwae Y, Ohsawa M, Uehara S, Sato KK, Hayashi T, Endo G.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 21
Issue: 7
Pages: 479-488
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 職業性胆管癌の臨床的特徴2014
Author(s)
久保正二、他
Organizer
第62回日本職業・災害医学会学術大会
Place of Presentation
神戸国際会議場(兵庫県 神戸市)
Year and Date
2014-11-16
Related Report
Invited
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