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Relationship between pancreatic cancer and adiponectin

Research Project

Project/Area Number 26462071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

Masaji Tani  滋賀医科大学, 医学部, 教授 (60236677)

Co-Investigator(Kenkyū-buntansha) 山上 裕機  和歌山県立医科大学, 医学部, 教授 (20191190)
川井 学  和歌山県立医科大学, 医学部, 准教授 (40398459)
岡田 健一  和歌山県立医科大学, 医学部, 講師 (50407988)
廣野 誠子  和歌山県立医科大学, 医学部, 講師 (60468288)
清水 敦史  和歌山県立医科大学, 医学部, 学内助教 (00637910)
宮澤 基樹  和歌山県立医科大学, 医学部, 助教 (90549734)
三宅 亨  滋賀医科大学, 医学部, 助教 (70581924)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / 線維化 / 大腸癌 / αーSMA / adiponectin / 線維芽細胞 / 発癌 / アディポネクチン
Outline of Final Research Achievements

Fibrosis is the important factors for fibrous adhesion in fatty patients, and pancreatic cancer is fibrous tumor. Therefore, we performed preliminary study of both serum adiponectin concentration and influence of fibrosis. Preoperative serum adiponectin concentration was 8.6+/-10.9μg/ml and they were decreased after operation. On the other hands, we estimated fibrosis at the positive area using αSMA. When cut-off value of αSMA positive cells was 20%, patients with low αSMA positive cells (<20%) significantly demonstrated poor survival than high αSMA patients (p<0.05). Fibrosis is the independent risk factor of the cancer survival.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Presentation (3 results)

  • [Presentation] ヒト大腸癌の組織型と線維化の関連性の検討2017

    • Author(s)
      生田大二、三宅 亨、他
    • Organizer
      第117回日本外科学会定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌におけるE/N Cadherin発現の臨床的意義2017

    • Author(s)
      徳田 彩、三宅 亨、他
    • Organizer
      第117回日本外科学会定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 進行膵体尾部癌に対する術中温熱化学療法2015

    • Author(s)
      赤堀 浩也, 塩見 尚礼, 前平 博充, 村上 耕一郎, 北村 直美, 河合 由紀, 山口 剛, 森 毅, 園田 寛道, 清水 智治, 村田 聡, 山本 寛, 目片 英治, 仲 成幸, 谷 眞至
    • Organizer
      日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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