| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We investigated the expression and functional relevance of hyaluronan (HA) network in pancreatic ductal adenocarcinoma (PDAC). The following findings were obtained: 1) One of the hyaluronidases, HYAL1, is overexpressed in PDAC; 2) RHAMM, a specific receptor for HA, is overexpressed in PDAC and correlates with its prognosis; 3) Addition of HA to the conditioned medium of PDAC cells stimulates their migration; 4) KIAA1199, a novel HA degrading enzyme, is overexpressed in PDAC. KIAA1199 in PDAC cells is induced by inflammation and enhances malignant behaviors (proliferation, migration, and invasion). These findings suggest that the whole process of HA metabolism is activated in PDAC and may play a critical role in malignant progression.
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