2016 Fiscal Year Final Research Report
Functional analysis of hyaluronan network during pancreatic cancer progression using microarrays
Project/Area Number |
26462076
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
Sato Norihiro 産業医科大学, 医学部, 講師 (20423527)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | ヒアルロン酸 / 膵癌 / 浸潤 / 遊走 / KIAA1199 |
Outline of Final Research Achievements |
We investigated the expression and functional relevance of hyaluronan (HA) network in pancreatic ductal adenocarcinoma (PDAC). The following findings were obtained: 1) One of the hyaluronidases, HYAL1, is overexpressed in PDAC; 2) RHAMM, a specific receptor for HA, is overexpressed in PDAC and correlates with its prognosis; 3) Addition of HA to the conditioned medium of PDAC cells stimulates their migration; 4) KIAA1199, a novel HA degrading enzyme, is overexpressed in PDAC. KIAA1199 in PDAC cells is induced by inflammation and enhances malignant behaviors (proliferation, migration, and invasion). These findings suggest that the whole process of HA metabolism is activated in PDAC and may play a critical role in malignant progression.
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Free Research Field |
膵癌分子生物学
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