| Project/Area Number |
26462104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Sasaki Takeshi 浜松医科大学, 医学部, 技術専門員 (20397433)
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| Co-Investigator(Kenkyū-buntansha) |
成 憲武 名古屋大学, 未来社会創造機構(医), 特任准教授 (30378228)
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| Co-Investigator(Renkei-kenkyūsha) |
UNNO Naoki 浜松医科大学, 医学部, 特任研究員 (20291958)
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| Research Collaborator |
SATO Kohji 浜松医科大学, 医学部, 教授
KUZUYA Masafumi 名古屋大学, 大学院・医学系研究科, 教授
TANAKA Hiroki 浜松医科大学, 医学部, 助教
SANO Masaki 浜松医科大学, 医学部, 助教
TAKEMURA Ayana 浜松医科大学, 医学部
KATO Sachiho 浜松医科大学, 医学部
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腹部大動脈瘤 / B細胞 / IRA-B細胞 / サイトカイン / GM-CSF / 炎症細胞 / 腹部大動脈瘤(AAA) / 炎症 / 免疫細胞 / プロテアーゼ / 血管周囲脂肪組織 / アディポカイン / 肥満細胞 / 脂肪細胞 / アディポネクチン / レプチン / マクロファージ / 好中球 / GM-CSF受容体 |
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| Outline of Final Research Achievements |
Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. Innate response activator (IRA)-B cells synthesize granulocyte macrophage colony-stimulating factor (GM-CSF), and facilitatory and inhibitory effects of GM-CSF on atherogensis have been reported. However, the role of IRA-B cells in AAA formation is not clear. Therefore, we investigated localization of IRA-B cell like cells in AAA lesion, and the expression of GM-CSF and its receptor.
The expression of GM-CSF and some markers of IRA-B cell were observed in AAA lesion, and significantly higher expression of GM-CSF in AAA lesion was observed compared with control. In addition, GM-CSF receptors and its higher expression also were detected in AAA specimen. Furthermore, the GM-CSF receptors were identified in macrophages and neutrophils. These results suggest that IRA-B cell like cells localized in AAA lesion, and GM-CSF derived from IRA-B cell like cell and its receptor may participate in AAA formation.
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