Tumor suppression mechanism through anti-inflammation and anit-fibrosis in non-small cell lung cancer
| Project/Area Number |
26462129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
前原 喜彦 九州大学, 医学研究院, 教授 (80165662)
岡本 龍郎 九州大学, 医学研究院, 准教授 (80568626)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非小細胞肺癌 / 抗炎症 / 抗線維化 / 肺癌悪性度 / 間質性肺炎合併肺癌 / 炎症性サイトカイン / 繊維化サイトカイン / 線維化因子 / 免疫組織化学的検討 / 病理病期IA期 / 術後再発 / 間質性肺炎マーカー / 血清KL-6値 |
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| Outline of Final Research Achievements |
(1)Analysis of inflammatory cytokines and malignant grade of lung cnacer was done.(Results) VEGF（p=0.047）、Fibronectin（p=0.011) and HGF（p=0.02) mRNA expression were significantly associated with intratumoral vessel invasion.
(2)Multicytokines analysis of IP or non-IP NSCLC was performed. (Results) ①In NSCLC without IP, IL-6 mRNA expression in non-cancerous lesion was significantly higher than that in cancerous lesion. In addition, VEGF mRNA expression in cancerous lesion was significantly higher. ②In NSCLC with IP, IL-6 mRNA expression in non-cancerous lesion was also significantly higher. On the other hand, IL-1β,VEGF and FGF mRNA expression in cancerous lesion were significantly higher, respectively. ③FGF mRNA expression both in cancerous and non-cancerous lesion with IP, was significantly higher than that with non-IP.
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Report
(4 results)
Research Products
(1 results)
