Elucidation of novel molecular mechanisms underlying the development of cerebral vasospasm after subarachnoid hemorrhage and searching for biomarkers of vasospasm
| Project/Area Number |
26462164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
溝口 昌弘 九州大学, 医学研究院, 共同研究員 (50380621)
天野 敏之 九州大学, 医学研究院, 共同研究員 (70448413)
中溝 玲 九州大学, 医学研究院, 共同研究員 (80529800)
栗田 浩樹 埼玉医科大学, 医学部, 教授 (70262003)
竹田 理々子 埼玉医科大学, 医学部, 講師 (70649847)
池田 俊貴 埼玉医科大学, 医学部, 講師 (90406968)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | くも膜下出血 / 脳血管攣縮 / 血管平滑筋収縮 / 血管リモデリング / バイオマーカー |
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| Outline of Final Research Achievements |
Cerebral vasospasm after subarachnoid hemorrhage (SAH) is characterized by delayed and prolonged contraction of cerebral arteries, which causes cerebral ischemia, thereby determining the prognosis of both life and neurologic function of SAH patients. The molecular mechanisms of cerebral vasospasm remain to be elucidated. In this study, we investigated the roles of several molecules including relaxin, TIMP-1 and MMP9, which were revealed to be upregulated in the rabbit basilar artery after SAH by microarray analysis, in increased vascular contractility after SAH. As a result, it is suggested that down-regulation of relaxin receptor expression and impaired TIMP-1/MMP9 balance contribute to acquiring persistency of vascular smooth muscle contraction and enhancement of vascular remodeling after SAH, respectively.
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Report
(4 results)
Research Products
(37 results)
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[Presentation] Upregulation of relaxin after experimental subarachnoid hemorrhage.2015
Author(s)
Kikkawa Y, Matsuo S, Kurogi R, Takeda R, Ikeda T, Yamaguchi Y, Nakajima H, Ogura T, Ooigawa H, Kurita H
Organizer
14th Asian Australasian Congress of Neurological Surgeons (AACNS)
Place of Presentation
Jeju Island, Korea
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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[Presentation] Chronological change of vasospsm and microcirculatory disturbance after experimental ubarachnoid hemorrhage.2015
Author(s)
Kikkawa Y, Kurogi R, Matsuo S, Takeda R, Ikeda T, Yamaguchi Y, Nakajima H, Ogura T, Ooigawa H, Kurita H
Organizer
14th Asian Australasian Congress of Neurological Surgeons (AACNS)
Place of Presentation
Jeju Island, Korea
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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[Presentation] Correlation between vasospasm and microcirculatory disturbance in early and delayed phase following experimental subarachnoid hemorrhage.2015
Author(s)
Kikkawa Y, Kurogi R, Matsuo S, Mizoguchi M, Kayahara T, Yokosako S, Ueno R, Yamaguchi Y, Fushihara G, Ikeda T, Takeda R, Ogura T, Ooigawa H, Sasaki T, Kurita H:
Organizer
International Stroke Conference 2015
Place of Presentation
Nashville, USA
Year and Date
2015-02-11 – 2015-02-13
Related Report
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[Presentation] Upregulation of relaxin after experimental subarachnoid hemorrhage2015
Author(s)
Kikkawa Y, Matsuo S, Kurogi R, Mizoguchi M, Kayahara T, Yokosako S, Ueno R, Yamaguchi Y, Fushihara G, Ikeda T, Takeda R, Ogura T, Ooigawa H, Sasaki T, Kurita H:
Organizer
International Stroke Conference 2015
Place of Presentation
Nashville, USA
Year and Date
2015-02-11 – 2015-02-13
Related Report
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[Presentation] Correlation between cerebral vasospasm and microcirculatory disturbance in early and delayed phase after experimental subarachnoiod hemorrhage.2014
Author(s)
Kikkawa Y, Kurogi Y, Matsuo S, Nakamizo A, MIzoguchi M, Take Y, Kayahara T, Yokosako S, Ueno R, Yamaguchi Y, Fushihara G, Ikeda T, Takeda R, Ogura T, Ooigawa H, Kurita H
Organizer
15th European Congress of Neurosurgery
Place of Presentation
Plague, Czech Republic
Year and Date
2014-10-12 – 2014-10-17
Related Report
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[Presentation] Role of relaxin in the development of cerebral vasospasm after subarachnoid hemorrhage.2014
Author(s)
Kikkawa Y, Matsuo S, Kurogi Y, Nakamizo A, MIzoguchi M, Take Y, Kayahara T, Yokosako S, Ueno R, Yamaguchi Y, Fushihara G, Ikeda T, Takeda R, Ogura T, Ooigawa H, Kurita H
Organizer
15th European Congress of Neurosurgery
Place of Presentation
Plague, Czech Republic
Year and Date
2014-10-12 – 2014-10-17
Related Report
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[Presentation] Modern management of aneurymal subarachnoid hemorrhage and cerebral vasospasm2014
Author(s)
Kikkawa Y, Takeda R, Ikeda T, Fushihara G, Yamaguchi Y, Ueno R, Yokosako S, Kayahara T, Take Y, Ooigawa H, Kurita H
Organizer
The 12th Korean and Japanese Friendship Conference on Surgery for Cerebral Stroke
Place of Presentation
大阪
Year and Date
2014-09-26 – 2014-09-27
Related Report
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