A study of dopamine release in Parkinson'disease-deep brain stimulation model rat by using PET scan
Project/Area Number |
26462201
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
浅川 哲也 浜松医科大学, 医学部, 特任助教 (00469917)
野崎 孝雄 浜松医科大学, 医学部附属病院, 助教 (10598494)
間賀田 泰寛 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399)
難波 宏樹 浜松医科大学, 医学部, 教授 (60198405)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | パーキンソン病 / 脳深部刺激術 / ドパミン / 内側前縦束 / ラットパーキンソン病モデル / ドパミン受容体 / 視床下核刺激 / 淡蒼球刺激 |
Outline of Final Research Achievements |
Parkinson disease is characterized with irreversible dopamine neuron degeneration and has high incidence rate, which is more than 1 % of whole population. We are continuously studying the dopamine receptor change of dopamine release with deep brain stimulation using Parkinson’s model rats. This year, we observed the dopamine 2 (D2) receptor change in striatum after 6-OHDA injection into the medial forebrain bundle (MFB) in Parkinson’s model rats. We noticed D2 receptor up-regulation in striatum start from not 2 weeks or 3 weeks but 4 weeks after 6-OHDA injection into MFB.
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Report
(5 results)
Research Products
(6 results)
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[Journal Article] Human Behavioral Assessments in Current Research of Parkinson's Disease.2016
Author(s)
Asakawa T, Fang H, Sugiyama K, Nozaki T, Kobayashi S, Hong Z, Suzuki K, Mori N, Yang Y, Hua F, Ding G, Wen G, Namba H, Xia Y.
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Journal Title
Neurosci Biobehav Rev
Volume: Jun 29
Pages: 1-20
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Animal behavioral assessments in current research of Parkinson's disease2016
Author(s)
Asakawa T*, Fang H, Sugiyama K, Nozaki T, Hong Z, Yang Y, Hua F, Ding G, Chao D, Fenoy AJ, Villarreal SJ, Onoe H, Suzuki K, Mori N, Namba H, Xia Y*.
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Journal Title
Neurosci Biobehav Rev
Volume: 65
Pages: 63-94
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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