| Project/Area Number |
26462201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅川 哲也 浜松医科大学, 医学部, 特任助教 (00469917)
野崎 孝雄 浜松医科大学, 医学部附属病院, 助教 (10598494)
間賀田 泰寛 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399)
難波 宏樹 浜松医科大学, 医学部, 教授 (60198405)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | パーキンソン病 / 脳深部刺激術 / ドパミン / 内側前縦束 / ラットパーキンソン病モデル / ドパミン受容体 / 視床下核刺激 / 淡蒼球刺激 |
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| Outline of Final Research Achievements |
Parkinson disease is characterized with irreversible dopamine neuron degeneration and has high incidence rate, which is more than 1 % of whole population. We are continuously studying the dopamine receptor change of dopamine release with deep brain stimulation using Parkinson’s model rats. This year, we observed the dopamine 2 (D2) receptor change in striatum after 6-OHDA injection into the medial forebrain bundle (MFB) in Parkinson’s model rats. We noticed D2 receptor up-regulation in striatum start from not 2 weeks or 3 weeks but 4 weeks after 6-OHDA injection into MFB.
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