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Changes in BBB functions and accumulation of amyloid beta in chronic cerebral hypoperfusion

Research Project

Project/Area Number 26462204
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Kato Hiroki  大阪大学, 医学系研究科, 講師 (20448054)

Co-Investigator(Kenkyū-buntansha) 畑澤 順  大阪大学, 医学系研究科, 教授 (70198745)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsPET / SPECT / 脳慢性低灌流 / 脳循環代謝 / 神経炎症 / 脳血流 / 脳酸素代謝 / 慢性低灌流 / アストロサイト
Outline of Final Research Achievements

Cerebral hypoperfusion rat model by occlusion of bilateral common carotid arteries is a representative animal model for investigation of chronic cerebral hypoperfusion. Cerebral metabolic rate of oxygen in relation to cerebral blood flow (CBF) and cerebral blood volume has not yet been clarified in the animal models. We clarified cerebral perfusion and oxygen metabolism in the cerebral hypoperfusion rat model in the acute and the chronic phases under anesthesia by O-15 PET based on steady-state method.
SPECT is one of the important modalities for evaluation of CBF in the patients with cerebral hypoperfusion. We clarified CT-based reconstruction method by using recently developed integrated SPECT/CT significantly improved detectability of CBF reduction in the patients.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Genetic and Environmental Influences on Regional Brain Uptake of 18F-FDG: A PET Study on Monozygotic and Dizygotic Twins.2016

    • Author(s)
      Watanabe S, Kato H, Shimosegawa E, Hatazawa J.
    • Journal Title

      J Nucl Med.

      Volume: 57 Issue: 3 Pages: 392-397

    • DOI

      10.2967/jnumed.115.164004

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses.2016

    • Author(s)
      Kato H, Shimosegawa E, Fujino K, Hatazawa J.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 7 Pages: e0159505-e0159505

    • DOI

      10.1371/journal.pone.0159505

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 11C-Acetate PET Imaging in Patients with Multiple Sclerosis.2014

    • Author(s)
      Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 11 Pages: e111598-e111598

    • DOI

      10.1371/journal.pone.0111598

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A dynamic parameter of I-123 iomazenil SPECT can be an indicator of the risk of cerebral ischemia2016

    • Author(s)
      Hiroki Kato, Kayako Isohashi, Eku Shimosegawa, Jun Hatazawa
    • Organizer
      日本脳循環代謝学会(BRAIN Japan 2016)
    • Place of Presentation
      Tokushima/Japan
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] I-123 iomazenil SPECT can evaluate the risk of cerebral ischemia2016

    • Author(s)
      Hiroki Kato, Kayako Isohashi, Yasukazu Kanai, Mitsuaki Tatsumi, Katsufumi Kajimoto, Eku Shimosegawa, Jun Hatazawa
    • Organizer
      The 56th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine
    • Place of Presentation
      Nagoya/Japan
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pharmacokinetic parameters of I-123 iomazenil can predict the risk of ischemic stroke2016

    • Author(s)
      Hiroki Kato, Kayako Isohashi, Tadashi Watabe, Yasukazu Kanai, Sadahiro Naka, Mitsuaki Tatsumi, Eku Shimosegawa, Jun Hatazawa
    • Organizer
      SNMMI'16 Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      San Diego/USA
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parametric image analysis of brain images (including software practice)2016

    • Author(s)
      Hiroki Kato
    • Organizer
      Workshop: Nuclear Medicine Techniques in Neurological Diseases: Emphasis on Oncology and Neurology (ICNMP-PA)
    • Place of Presentation
      Senri Life Science Center, Osaka, Japan
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pharmacokinetic parameters of I-123 iomazenil in chronic cerebrovascular hypoperfusion2015

    • Author(s)
      Hiroki Kato, Kayako Isohashi, Yasukazu Kanai, Mitsuaki Tatsumi, Katsufumi Kajimoto, Eku Shimosegawa, Jun Hatazawa
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Attenuation correction by CT can improve the lesion detectability of brain SPECT2015

    • Author(s)
      Hiroki Kato, Mana Ishibashi, Kayako Isohashi, Mitsuaki Tatsumi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa
    • Organizer
      EANM'15 Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Hamburg/Germany
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Altered astrocyte activity in multiple sclerosis patients can be detected by C-11 acetate PET2014

    • Author(s)
      H.Kato, K.Isohashi, M.Ishibashi, T.Watabe, S.Naka, Y.Kanai, M.Tatsumi, E.Shimosegawa, J.Hatazawa
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Detection of altered astrocyte reactivity in multiple sclerosis patients by C-11 acetate PET2014

    • Author(s)
      Hiroki Kato, Kazushiro Takata, Eku Shimosegawa, Kayako Isohashi, Tadashi Watabe, Mitsuaki Tatsumi, Yasukazu Kanai, Sadahiro Naka, Yuji Nakatsuji, Jun Hatazawa
    • Organizer
      SNMI 2014
    • Place of Presentation
      St. Louis Convention Center, St. Louis, MO
    • Year and Date
      2014-06-07 – 2014-06-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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