Changes in BBB functions and accumulation of amyloid beta in chronic cerebral hypoperfusion

• Project/Area Number: 26462204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Kato Hiroki 大阪大学, 医学系研究科, 講師 (20448054)
• Co-Investigator(Kenkyū-buntansha): 畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: PET / SPECT / 脳慢性低灌流 / 脳循環代謝 / 神経炎症 / 脳血流 / 脳酸素代謝 / 慢性低灌流 / アストロサイト

Outline of Final Research Achievements

Cerebral hypoperfusion rat model by occlusion of bilateral common carotid arteries is a representative animal model for investigation of chronic cerebral hypoperfusion. Cerebral metabolic rate of oxygen in relation to cerebral blood flow (CBF) and cerebral blood volume has not yet been clarified in the animal models. We clarified cerebral perfusion and oxygen metabolism in the cerebral hypoperfusion rat model in the acute and the chronic phases under anesthesia by O-15 PET based on steady-state method.
SPECT is one of the important modalities for evaluation of CBF in the patients with cerebral hypoperfusion. We clarified CT-based reconstruction method by using recently developed integrated SPECT/CT significantly improved detectability of CBF reduction in the patients.

Research Products

• [Journal Article] Genetic and Environmental Influences on Regional Brain Uptake of 18F-FDG: A PET Study on Monozygotic and Dizygotic Twins. (2016)
  • Author(s): Watanabe S, Kato H, Shimosegawa E, Hatazawa J.
  • Journal Title: J Nucl Med. Volume: 57 Issue: 3 Pages: 392-397
  • DOI: 10.2967/jnumed.115.164004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses. (2016)
  • Author(s): Kato H, Shimosegawa E, Fujino K, Hatazawa J.
  • Journal Title: PLoS One. Volume: 11 Issue: 7 Pages: e0159505-e0159505
  • DOI: 10.1371/journal.pone.0159505
  • Peer Reviewed / Open Access
• [Journal Article] 11C-Acetate PET Imaging in Patients with Multiple Sclerosis. (2014)
  • Author(s): Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.
  • Journal Title: PLoS One. Volume: 9 Issue: 11 Pages: e111598-e111598
  • DOI: 10.1371/journal.pone.0111598
  • Peer Reviewed / Open Access
• [Presentation] A dynamic parameter of I-123 iomazenil SPECT can be an indicator of the risk of cerebral ischemia (2016)
  • Author(s): Hiroki Kato, Kayako Isohashi, Eku Shimosegawa, Jun Hatazawa
  • Organizer: 日本脳循環代謝学会(BRAIN Japan 2016)
  • Place of Presentation: Tokushima/Japan
  • Year and Date: 2016-11-11
• [Presentation] I-123 iomazenil SPECT can evaluate the risk of cerebral ischemia (2016)
  • Author(s): Hiroki Kato, Kayako Isohashi, Yasukazu Kanai, Mitsuaki Tatsumi, Katsufumi Kajimoto, Eku Shimosegawa, Jun Hatazawa
  • Organizer: The 56th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine
  • Place of Presentation: Nagoya/Japan
  • Year and Date: 2016-11-03
• [Presentation] Pharmacokinetic parameters of I-123 iomazenil can predict the risk of ischemic stroke (2016)
  • Author(s): Hiroki Kato, Kayako Isohashi, Tadashi Watabe, Yasukazu Kanai, Sadahiro Naka, Mitsuaki Tatsumi, Eku Shimosegawa, Jun Hatazawa
  • Organizer: SNMMI'16 Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: San Diego/USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] Parametric image analysis of brain images (including software practice) (2016)
  • Author(s): Hiroki Kato
  • Organizer: Workshop: Nuclear Medicine Techniques in Neurological Diseases: Emphasis on Oncology and Neurology (ICNMP-PA)
  • Place of Presentation: Senri Life Science Center, Osaka, Japan
  • Year and Date: 2016-05-23
  • Int'l Joint Research / Invited
• [Presentation] Pharmacokinetic parameters of I-123 iomazenil in chronic cerebrovascular hypoperfusion (2015)
  • Author(s): Hiroki Kato, Kayako Isohashi, Yasukazu Kanai, Mitsuaki Tatsumi, Katsufumi Kajimoto, Eku Shimosegawa, Jun Hatazawa
  • Organizer: 第55回日本核医学会学術総会
  • Place of Presentation: ハイアットリージェンシー東京
  • Year and Date: 2015-11-05
• [Presentation] Attenuation correction by CT can improve the lesion detectability of brain SPECT (2015)
  • Author(s): Hiroki Kato, Mana Ishibashi, Kayako Isohashi, Mitsuaki Tatsumi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa
  • Organizer: EANM'15 Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Hamburg/Germany
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Altered astrocyte activity in multiple sclerosis patients can be detected by C-11 acetate PET (2014)
  • Author(s): H.Kato, K.Isohashi, M.Ishibashi, T.Watabe, S.Naka, Y.Kanai, M.Tatsumi, E.Shimosegawa, J.Hatazawa
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] Detection of altered astrocyte reactivity in multiple sclerosis patients by C-11 acetate PET (2014)
  • Author(s): Hiroki Kato, Kazushiro Takata, Eku Shimosegawa, Kayako Isohashi, Tadashi Watabe, Mitsuaki Tatsumi, Yasukazu Kanai, Sadahiro Naka, Yuji Nakatsuji, Jun Hatazawa
  • Organizer: SNMI 2014
  • Place of Presentation: St. Louis Convention Center, St. Louis, MO
  • Year and Date: 2014-06-07 – 2014-06-11