| Project/Area Number |
26462214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Suzuki Junpei 札幌医科大学, 医学部, 研究員 (00572596)
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 祐典 札幌医科大学, 医学部, 講師 (20538136)
鰐渕 昌彦 札幌医科大学, 医学部, 准教授 (30343388)
三上 毅 札幌医科大学, 医学部, 講師 (30372816)
中崎 公仁 札幌医科大学, 医学部, 研究員 (70722461)
長濱 宏史 札幌医科大学, 医学部, 研究員 (20725676)
浪岡 愛 札幌医科大学, 医学部, 研究員 (60748995)
浪岡 隆洋 札幌医科大学, 医学部, 研究員 (70748996)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳梗塞 / 神経可塑性 / 骨髄幹細胞 |
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| Outline of Final Research Achievements |
Intravenous infusion of mesenchymal stem cells (MSCs) from adult bone marrow ameliorates functional deficits in rat cerebral infarction models. In this study, we found functional improvements evaluated with behavioral testing following systemic administration of MSCs in stroke. Immunohistochemical analysis demonstrated that synaptogenesis was induced around the ischemic lesion in the MSC treated group. Collectively, neural plasticity might contribute to the functional recovery following intravenous infusion of MSCs in a rat model of stroke.
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