Development of a new treatment method of intractable fractures using carbon dioxide
| Project/Area Number |
26462266
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
李 相亮 神戸大学, 医学部附属病院, 助教 (40533732)
岩倉 崇 神戸大学, 医学研究科, 医学研究員 (60437473)
|
|---|
| Research Collaborator |
KUROIWA Yu
ARAKURA Michio
TAKAHARA Syunsuke
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 骨折治癒促進 / 難治性骨折 / 炭酸ガス / 骨再生 / 骨欠損 |
|---|
| Outline of Final Research Achievements |
We conducted an animal study as a pre-clinical trial to develop a new treatment method of an intractable fractures. Bone defect was created in the rat femoral shaft and stabilized with external fixator. After the surgery to create bone defect model, the healing process was compared between a group with transcutaneous carbon dioxide absorption and a control group without it. Bone healing was assessed radiographically and histologically. The bone mineral density of the newly formed bone was measured. The mechanical properties of the excised femurs were assessed. We found that bone healing was accelerated through an acceleration of endochondral ossification by the transcutaneous carbon dioxide absorption. Our results suggested that the transcutaneous carbon dioxide absorption could be a beneficial treatment option of intractable fractures.
|
Report
(4 results)
Research Products
(8 results)
-
-
-
-
-
[Presentation] The Effects of the Duration of Transcutaneous CO2 Application on the Facilitatory Effect in Rat Fracture Repair2015
Author(s)
Takashi Iwakura, Takahiro Niikura, Sang Yang Lee, Etsuko Okumachi, Takahiro Waki, Syunsuke Takahara, Michio Arakura, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka
Organizer
The 61th Annual Meeting of Orthopaedic Research Society
Place of Presentation
Las Vegas, USA
Year and Date
2015-03-28 – 2015-03-31
Related Report
-
-
-
