| Project/Area Number |
26462328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Akita University |
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Principal Investigator |
Nagasaki Go 秋田大学, 医学部, 助教 (60292380)
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| Co-Investigator(Kenkyū-buntansha) |
安部 恭子 秋田大学, 医学部, 助教 (30311575)
西川 俊昭 秋田大学, 医学(系)研究科(研究院), 教授 (50156048)
佐藤 浩司 秋田大学, 医学部, 助教 (80333938)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 水素ガス / ラット / 前脳虚血モデル / 脳低温療法 / 一過性前脳虚血モデル / 虚血性脳傷害 / 虚血性脳障害 |
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| Outline of Final Research Achievements |
We examined whether combined treatment with 1.3% hydrogen gas and hypothermia reduces brain injury after transient forebrain ischemia in rats compared with either treatment alone. Rats were subjected to 10 minutes of forebrain ischemia followed by 7 days of reperfusion. Four groups were tested: group C (control); group G (hydrogen gas); group H (hypothermia, 34℃); and group GH (hydrogen gas + hypothermia). Neuronal damage in the CA1 subfield of the hippocampus was evaluated microscopically and graded on a damage score scale of 1,no damage～6, no intact neuron. The median injury score [interquartile range] was 5[0] for the group C, 4.5[2] for the group G, 3.5[1] for the group H and 2.5[2] for the group GH. The current study suggested that the neuroprotective efficacy of hypothermia could be increased by 1.3% hydrogen gas inhalation.
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