A role of the endocannabinoid system in a favorable recovery profile after propofol anesthesia

Research Project

Project/Area Number	26462330
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology
Research Institution	Niigata University
Principal Investigator	Petrenko Andrey 新潟大学, 医歯学系, 助教 (30397153)
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords	propofol / anesthesia recovery / endocannabinoid system / cognitive function / emotional function
Outline of Final Research Achievements	Patients recovering from propofol anesthesia often report a feeling of well-being (pleasant) mood. Cannabinoids are one of the substances that can produce similar effect. We proposed and set out to test the hypothesis that the increase in endogenous cannabinoid concentration could be responsible for positive mood changing effect observed after propofol anesthesia. The results of this study suggest that endocannabinoid system may be involved in a positive affective state that is observed during the recovery from propofol anesthesia.

Report

(5 results)