Postoperative impairment of cognitive function in rats: A possible role of hippocampal neurogenesis

• Project/Area Number: 26462350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: University of Tsukuba
• Principal Investigator: YAMASHITA SOICHIRO 筑波大学, 医学医療系, 講師 (10455933)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 神経新生 / 術後高次機能障害 / 手術 / 全身麻酔 / 海馬歯状回

Outline of Final Research Achievements

This study was conducted to evaluate the effects of surgery on hippocampal neurogenesis and postoperative learning and memory function. In addition, preoperative prophylactic treatment of fluoxetine for the surgery-induced decrease of hippocampal neurogenesis and postoperative learning and memory dysfunction were determined. Hippocampal neurogenesis and postoperative learning and memory function were affected after surgery in 3 months rats. Preoperative fluoxetine administration reduced the surgery-induced decrease of hippocampal neurogenesis and postoperative learning and memory dysfunction. These results were related with the concentration of brain-derived neutrophic factor (BDNF) in the hippocampus.