Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
Aromatase inhibitor(Letrozole,1 or 5 mg/kg) reduced threshold value of pain for a Formalin test, neuropathic pain (Seltzer model) and a cancer bone metastases pain model. G-protein-coupled estrogen receptor, GPR30 inhibitor (G15) of the cell membrane localization increased threshold value of pain for each animal models. We examined a manifestation immunohistochemically change of GPR30 and aromatase in the spinal cord in a neuropathic pain and a cancer pain mode rats. Athreshold value of pain decrease with the aromatase inhibitor administration less had the significant difference with the ovariectomy rat as a post-menopausal model. Using each spine fusion graft, we compared the microglial activation by the IBa1 immunostaining and examined association with the pain as compared with a control in each miRNA.
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