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Functional analysis of FAM110 gene family in the prostate cancer

Research Project

Project/Area Number 26462395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionAkita University

Principal Investigator

Tsuruta Hiroshi  秋田大学, 医学部, 助教 (90466590)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords前立腺癌 / 細胞増殖 / 細胞浸潤 / N-カドヘリン / 細胞骨格 / FAM110 gene family
Outline of Final Research Achievements

In the functional analysis of FAM110 gene family (FAM110A, B and C), we found that cell invasiveness was increased in FAM110A stable expressed cancer cell line and cell proliferation was suppressed in FAM110C stable expressed cancer cell line although these mechanisms were still unknown. In the FAM110A transient transfected prostate cancer cell line, N-cadherin mRNA expression level was increased, on the other hand, this expression level was suppressed in the FAM110C transient transfected prostate cancer cell line. These results suggested that there was an inverse relationship between the functions of FAM110A and FAM110C. Additionally, FAM110C transient transfected cell line showed suppression of cell proliferation. These results suggested FAM110C gene play a role in tumor suppression.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Comparison of surgical invasiveness between open and robot-assisted radical cystectomies: differences in the systemic inflammatory cytokine level.2016

    • Author(s)
      Hiroshi Tsuruta
    • Organizer
      34th World Congress of Endourology and SWL.
    • Place of Presentation
      ケープタウン、南アフリカ
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of the clinical outcome and surgical invasiveness for living donor nephrectomy between conventional laparoscopic surgery and single-port surgery2015

    • Author(s)
      Hiroshi Tsuruta
    • Organizer
      World congress of Endourology and SWL
    • Place of Presentation
      イギリス、ロンドン
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 前立腺癌におけるαカテニン結合蛋白, FAM110Aの関与.2014

    • Author(s)
      鶴田 大
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The expression and function of FAM110A in human prostate cancer.2014

    • Author(s)
      Hiroshi Tsuruta
    • Organizer
      29th Annual European Association of Urology Congress
    • Place of Presentation
      ストックホルム、スウェーデン
    • Year and Date
      2014-04-11 – 2014-04-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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