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Search for therapeutic targets from novel prognostic-related genes based on comprehensive gene expression analysis of kidney cancer

Research Project

Project/Area Number 26462418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionFukushima Medical University

Principal Investigator

Yanagida Tomohiko  福島県立医科大学, 医学部, 講師 (20363765)

Co-Investigator(Kenkyū-buntansha) 羽賀 宣博  福島県立医科大学, 医学部, 助教 (50586617)
小島 祥敬  福島県立医科大学, 医学部, 教授 (60305539)
相川 健  福島県立医科大学, 医学部, 准教授 (80295419)
石橋 啓  福島県立医科大学, 医学部, 准教授 (90347211)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords腎癌の予後予測 / 腎癌の網羅的遺伝子発現解析 / 38遺伝子セット / 腎癌予後不良38遺伝子 / 特許取得 / 学会賞 / 国際学会での成果報告 / 特許申請 / 学会賞の受賞 / 国際学会での発表 / 国際特許申請
Outline of Final Research Achievements

Progressive renal cell carcinoma is a urological cancer that has a high mortality rate and is difficult to treat. Since it shows diversity in the clinical course, there is a need for a method to predict the outcome of prognosis and therapeutic drugs. In this study, comprehensive gene expression analysis was performed on clear cell renal cell carcinoma, which accounts for more than 80% of kidney cancer. We confirmed that the classification in the gene expression profile strongly correlated with disease prognosis of clear cell renal cell carcinoma. Furthermore, it was suggested that clinically clear cell renal cell carcinoma has a difference in the therapeutic effect of targeted therapy in each of three subgroups based on the expression of 38 genes. From these results, it was suggested that this classification could be applied to clinical prognostic predictions and therapeutic drug selection.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Presentation (5 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Presentation] Relationship between the gene expression profiles of renal cell carcinoma and both prognostic molecular classification and response to targeted therapy2016

    • Author(s)
      柳田知彦
    • Organizer
      アメリカ国際学会(AUA)
    • Place of Presentation
      USA, San Diego
    • Year and Date
      2016-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between the Gene Expression Profiles of Renal Cell Carcinoma and Both Prognostic Molecular Classification and Response to Targeted Therapy2016

    • Author(s)
      柳田知彦
    • Organizer
      AUA 2016
    • Place of Presentation
      USA, San Diego
    • Year and Date
      2016-05-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between the gene expression profiles of renal cell carcinoma and both prognostic molecular classification and response to targeted therapy2016

    • Author(s)
      柳田知彦
    • Organizer
      第104回 日本泌尿器科学会総会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relationship between the Gene Expression Profiles of Renal Cell Carcinoma and Both Prognostic Molecular Classification and Response to Targeted Therapy2016

    • Author(s)
      柳田知彦
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 網羅的遺伝子発現による腎細胞癌の予後分類と分子標的治療の効果との関連性2015

    • Author(s)
      柳田知彦
    • Organizer
      第53回日本癌治療学会 ワークショップ62 腎癌分子標的治療の現状と将来展望
    • Place of Presentation
      京都府京都市
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 腎がんの悪性度の検査マーカー及び検査方法2014

    • Inventor(s)
      渡辺慎哉
    • Industrial Property Rights Holder
      渡辺慎哉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-30
    • Acquisition Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許庁2014

    • Inventor(s)
      渡辺慎哉
    • Industrial Property Rights Holder
      渡辺慎哉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-30
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2018-03-22  

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