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Establishment of the new strategy targeted to intracellular communication mechanism in castration resistant prostate cancer

Research Project

Project/Area Number 26462422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

NAIKI Taku  名古屋市立大学, 大学院医学研究科, 助教 (50551272)

Co-Investigator(Kenkyū-buntansha) 河合 憲康  名古屋市立大学, 大学院医学研究科, 講師 (20254279)
内木 綾  名古屋市立大学, 大学院医学研究科, 講師 (20509236)
安藤 亮介  名古屋市立大学, 大学院医学研究科, 助教 (30381867)
惠谷 俊紀  名古屋市立大学, 大学院医学研究科, 研究員 (30600754)
飯田 啓太郎  名古屋市立大学, 大学院医学研究科, 臨床研究医 (30713945)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords去勢抵抗性前立腺癌 / 細胞間連絡能 / 細胞間連絡機構 / コネキシン
Outline of Final Research Achievements

Prostate cancer growth is androgen sensitive, therefore, the first-line therapy of prostate cancer is androgen deprivation therapy like castration. However, the therapeutic efficacy is limited. Chemotherapy including taxane derivatives is next strategy in castration resistant prostate cancer (CRPC), however, the distribution of derivatives is various. Connexin 43 (Cx43) is a major gap junction (GJ) protein, and intracellular communication by using low molecular substances is normally performed through GJ. We previously established new CRPC animal models, and present study, cDNA microarray analyses revealed that Cx43 was suppressed in CRPC. Moreover, Cx43 regulates apoptotic signaling in castrated condition in new established Cx43 overexpressed prostate cancer cells. Therefore, GJ may play important roles in preventing castration resistant growth.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis.2016

    • Author(s)
      Kato H, Naiki-Ito A, Naiki T, Suzuki S, Yamashita Y, Sato S, Sagawa H, Kato A, Kuno T, Takahashi S.
    • Journal Title

      Oncotarget.

      Volume: 7 Issue: 2 Pages: 2009-2021

    • DOI

      10.18632/oncotarget.6511

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats.2015

    • Author(s)
      Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S.
    • Journal Title

      Carcinogenesis

      Volume: 36 Pages: 1539-49

    • DOI

      10.1093/carcin/bgv143

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Establishment of castration resistant prostate cancer animal model, and analyses for new innovative therapy.2016

    • Author(s)
      Naiki T
    • Organizer
      Hallyum and Nagoya City University joint symposium.
    • Place of Presentation
      名古屋市立大学病院(愛知県名古屋市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of castration resistant prostate cancer animal model, and analyses for new innovative therapy.2015

    • Author(s)
      Naiki T, Naiki-Ito A, Kawai N, Etani T, Shirai T, Kohri K, Yasui T, Takahashi S.
    • Organizer
      第74回日本癌学会学術総会 シンポジウム
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] GPX2 overexpression is involved in cell proliferation and prognosis of castration resistant prostate cancer2014

    • Author(s)
      内木 拓
    • Organizer
      伊勢志摩前立腺生物学シンポジウム2014
    • Place of Presentation
      三重県伊勢市
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 酸化ストレス応答機構を標的とした去勢抵抗性前立腺癌の病態解明と臨床応用2014

    • Author(s)
      内木 拓
    • Organizer
      第102回 日本泌尿器科学会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-04-25 – 2014-04-28
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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