| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Endometriosis is known as an inflammatory disease, and macrophages are involved in inflammation. Using human peritoneal macrophages, activation of nicotinic acethylcholine receptor (nAchR) led to suppress of inflammatory cytokines in macrophages in vitro. A mouse endometriosis model exhibited the effect of activation of nAchR on suppression of endometriotic lesions.
As Ach is known to be a transmitter of parasympathetic nerves, we hypothesized that in endometriosis patients, sympathetic nerves could be activated compared to parasympathetic nerves. We evaluated the condition of sympathetic/parasympathetic nerves in patients, and found the trend that serum concentration of noradrenaline, and the trait anxiety is higher in endometriosis patients rather than in non-endometriosis patients.
|
