| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In mouse model of fetal brain damage caused by maternal inflammation, the effect of prenatal administration of molecular hydrogen was examined. In this research, maternal inflammation raised overproduction of pro-inflammatory cytokines and the induction of oxidative stress in fetal brain, followed by increased number of apoptotic cells. In addition, excessive activated microglia is involved in this inflammation and oxidative stress induced brain damage. Molecular hydrogen repressed microglia, which is suggested to play a protective role against inflammation and oxidative stress induced brain damage.In addition, maternal administration of molecular hydrogen reduced the inflammation at the maternal-fetal interface, which is also related with the protective role against fetal brain damage.
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