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Role of HMGA1 on the pathogenesis of preeclampsia

Research Project

Project/Area Number 26462493
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionEhime University

Principal Investigator

Matsubara Keiichi  愛媛大学, 医学部附属病院, 准教授 (80263937)

Co-Investigator(Kenkyū-buntansha) 松原 裕子  愛媛大学, 医学部附属病院, 講師 (60403820)
那波 明宏  名古屋大学, 医学系研究科, 特任教授 (90242859)
Research Collaborator Yamamoto Sawa  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords妊娠高血圧症候群 / 血管内皮 / 絨毛細胞 / 高血圧 / HMGA1 / トロホブラスト / マウス
Outline of Final Research Achievements

On the third day after the implantation, trophoblastic cells were aggregated around the embryo and HMGA1 was observed in the cytoplasm as well as the nuclei derived from the preeclampsia model mouse. A part of HMGA1 was also released out of the cells by the implantation site. Furthermore, HMGA1 was transported into the cytoplasm from the nuclei in the human preeclamptic placenta. We demonstrated that DCA could stimulate the transportation of HMGA1 from nuclei to cytoplasm. In culture system, DCA decreased the proliferation and invasive capacity of extravillous trophoblast. In normal pregnancy, extravillous trophoblasts could invade into maternal decidua and uterine myometrium resulted in increased utero-maternal circulation to maintain the pregnancy. However, it is known that the effects were reduced in preeclampsia. Extra nuclear transport of HMGA1 is involved in the pathogenesis of preeclampsia through inhibiting extravillous trophoblasts invasion.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Extranuclear Translocation of High-Mobility Group A1 Reduces the Invasion of Extravillous Trophoblasts Involved in the Pathogenesis of Preeclampsia New Aspect of High-Mobility Group A1.2017

    • Author(s)
      Uchikura Y, Matsubara K, Muto Y, Matsubara Y, Fujioka T, Matsumoto T, Sugiyama T
    • Journal Title

      Reproductive Sciences

      Volume: 1 Issue: 12 Pages: 1-9

    • DOI

      10.1177/1933719117697254

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40&CD40 ligand pathway in pregnant mice.2016

    • Author(s)
      Keiichi Matsubara, Yuko Matsubara, Miki Mori, Yuka Uchikura, Katsuyuki Hamada, Toru Fujioka, Hisashi Hashimoto, and Takashi Matsumoto
    • Journal Title

      Hypertens Res

      Volume: 39 Issue: 6 Pages: 407-414

    • DOI

      10.1038/hr.2015.160

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Compensatory increase of left atrial external work to left ventricular dysfunction caused by afterload increase2015

    • Author(s)
      Inoue K, Asanuma T, Masuda K, Sakurai D, Higaki J, Nakatani S
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 308 Issue: 3 Pages: 4600-4614

    • DOI

      10.3390/ijms16034600

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of High-Mobility Group A1 Protein in Preeclampsia.2017

    • Author(s)
      Yuka Uchikura, Keiichi Matsubara, Yuko Matsubara, and Takashi Sugiyama.
    • Organizer
      64th Annual Scientific Meeting of Society for Reproductive Science
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] sFlt-1 Production Is Modulated Through the Activation of Angiotensin II Receptor Subtype 2 in Preeclampsia.2017

    • Author(s)
      Keiichi Matsubara, Yuko Matsubara, Yuka Uchikura, and Takashi Sugiyama. T
    • Organizer
      64th Annual Scientific Meeting of Society for Reproductive Science
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of high-mobility group A1 protein in trophoblast invasion2015

    • Author(s)
      Uchikura Y
    • Organizer
      European Congress of the International Society for the Study of Hypertension in Pregnancy
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 絨毛細胞の浸潤能におけるHMGA1の役割2015

    • Author(s)
      内倉友香,松原圭一,松原裕子,森 美妃
    • Organizer
      第67回 日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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