| Project/Area Number |
26462502
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
SHOJI Hiroki 金沢医科大学, 一般教育機構, 教授 (10263873)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
有川 智博 金沢医科大学, 一般教育機構, 講師 (70452670)
|
|---|
| Research Collaborator |
HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | ガレクチン / 胎盤 / 栄養膜細胞 / 浸潤 / オートファジー / レクチン |
|---|
| Outline of Final Research Achievements |
Galectins bind beta-galactoside, and have been shown to regulate immune-system and tumor invasion etc. We have previously shown that galectin 4 possibly has roles in regulation of acquirement of invasiveness in rat placental trophoblast cell line (Rcho-1). Expression of galactin 4 is specifically down regulated during the differentiation of Rcho-1 cells. In the present study, we have shown that galactin 4 may regulate cell-cell adhesion in Rcho-1 cells. Also, we have shown that autophagy may play important roles both in down-regulation of galactin 4 expression and in the acquirement of invasiveness. The results of present study suggested that Galectins and autophagy have important roles in regulation of acquirement of invasiveness in placental trophoblasts.
|
