Regulation of acquirement of invasiveness in placental trophoblasts by galectin family
| Project/Area Number |
26462502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHOJI Hiroki 金沢医科大学, 一般教育機構, 教授 (10263873)
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| Co-Investigator(Kenkyū-buntansha) |
有川 智博 金沢医科大学, 一般教育機構, 講師 (70452670)
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| Research Collaborator |
HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ガレクチン / 胎盤 / 栄養膜細胞 / 浸潤 / オートファジー / レクチン |
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| Outline of Final Research Achievements |
Galectins bind beta-galactoside, and have been shown to regulate immune-system and tumor invasion etc. We have previously shown that galectin 4 possibly has roles in regulation of acquirement of invasiveness in rat placental trophoblast cell line (Rcho-1). Expression of galactin 4 is specifically down regulated during the differentiation of Rcho-1 cells. In the present study, we have shown that galactin 4 may regulate cell-cell adhesion in Rcho-1 cells. Also, we have shown that autophagy may play important roles both in down-regulation of galactin 4 expression and in the acquirement of invasiveness. The results of present study suggested that Galectins and autophagy have important roles in regulation of acquirement of invasiveness in placental trophoblasts.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1,2 and 52015
Author(s)
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
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Journal Title
PLOS ONE
Volume: 10
Issue: 4
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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