The elucidation of the mechanism in cancer microenvironment by ovarian cancer secretion exosome and the development of a next-generation cancer therapy by the exosome.
Project/Area Number |
26462541
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Osaka Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大道 正英 大阪医科大学, 医学部, 教授 (10283764)
田中 良道 大阪医科大学, 医学部, 講師 (10625502)
金村 昌徳 大阪医科大学, 医学部, 非常勤講師 (40298782)
恒遠 啓示 大阪医科大学, 医学部, 講師 (70388255)
田辺 晃子 大阪医科大学, 医学部, 非常勤講師 (70454543)
寺井 義人 大阪医科大学, 医学部, 准教授 (90278531)
藤原 聡枝 大阪医科大学, 医学部, 助教 (90707960)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | エキソソーム / 卵巣癌 / 癌微小環境 / microRNA |
Outline of Final Research Achievements |
There are micro RNA and the small molecule protein as a convenient communication of information tool in the extracellular vesicles and exosome covered by the lipid bilayer membrane secreted from an ovarian cancer. We isolated exosome from the ovarian cancer patient's ascites and ovarian-veins serum, and extracted microRNA from exosome. Mir-34a related to the EpithelialMesenchymal Transition(EMT). Moreover, the expression of CD24 which is the EMT related protein in ovarian cancer is prognosis prediction marker for ovarian cancer patients.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.2017
Author(s)
Nakamura K, Terai Y, Tanabe A, Ono YJ, Hayashi M, Maeda K, Fujiwara S, Ashihara K, Nakamura M, Tanaka Y, Tanaka T, Tsunetoh S, Sasaki H, Ohmichi M.
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Journal Title
Oncol Rep
Volume: -
Issue: 6
Pages: 3189-3200
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gemcitabine as a molecular targeting agent that blocks the Akt cascade in platinum-resistant ovarian cancer.2014
Author(s)
Kawaguchi H, Terai Y, Tanabe A, Sasaki H, Takai M, Fujiwara S, Ashihara K, Tanaka Y, Tanaka T, Tsunetoh S, Kanemura M, Ohmichi M.
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Journal Title
J Ovarian Res.
Volume: 7
Issue: 1
Pages: 38-38
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The EMT (epithelial mesenchymaltransition protein expression indicates the metastasicc status and progesis in patient with ovarian cancer2014
Author(s)
Takai M, Terai Y, Kawaguchi H, Ashihara K, Fujiwara S, Tanaka T, Tsunetoh S, Tanaka Y, Sasaki H, Kanemura M, Tanabe A, Ohmichi M.
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Journal Title
Journal of ovarian research
Volume: 76
Issue: 1
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access