2016 Fiscal Year Final Research Report
The elucidation of the mechanism in cancer microenvironment by ovarian cancer secretion exosome and the development of a next-generation cancer therapy by the exosome.
| Project/Area Number |
26462541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エキソソーム / 卵巣癌 / 癌微小環境 |
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| Outline of Final Research Achievements |
There are micro RNA and the small molecule protein as a convenient communication of information tool in the extracellular vesicles and exosome covered by the lipid bilayer membrane secreted from an ovarian cancer. We isolated exosome from the ovarian cancer patient's ascites and ovarian-veins serum, and extracted microRNA from exosome. Mir-34a related to the EpithelialMesenchymal Transition(EMT). Moreover, the expression
of CD24 which is the EMT related protein in ovarian cancer is prognosis prediction marker for ovarian cancer patients.
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| Free Research Field |
婦人科悪性腫瘍
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