| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To analize the role of NKT cells and HDAC activity on eosinophilic chronic rhinosinusitis, we collected PBMC form patients. We investigated HDAC activity using HDAC activity kit, and found that HDAC activity was significantly decreased in patients of eosinophilic chronic rhinosinusitis. Furthermore, we investigated eosinophilic chronic rhinosinusitis patients before and after surgery, and found that Blood eosinophil count was significantly reduced after surgery in the eosinophilic chronic rhinosinusitis group. We also found that serum IL-5 tended to be reduced after surgery in eosinophilic chronic rhinosinusitis patients.
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