Role of NKT cells on eosinochilic chronic rhinosinusitis
Project/Area Number |
26462575
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Hokkaido University |
Principal Investigator |
Takagi Dai 北海道大学, 大学病院, 講師 (60374427)
|
Co-Investigator(Kenkyū-buntansha) |
中丸 裕爾 北海道大学, 大学病院, 講師 (20344509)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 好酸球性副鼻腔炎 / HDAC活性 / ヒストン / アセチル化 / 血液中好酸球 / サイトカイン / iNKT細胞 / NKT細胞 |
Outline of Final Research Achievements |
To analize the role of NKT cells and HDAC activity on eosinophilic chronic rhinosinusitis, we collected PBMC form patients. We investigated HDAC activity using HDAC activity kit, and found that HDAC activity was significantly decreased in patients of eosinophilic chronic rhinosinusitis. Furthermore, we investigated eosinophilic chronic rhinosinusitis patients before and after surgery, and found that Blood eosinophil count was significantly reduced after surgery in the eosinophilic chronic rhinosinusitis group. We also found that serum IL-5 tended to be reduced after surgery in eosinophilic chronic rhinosinusitis patients.
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Report
(4 results)
Research Products
(18 results)