Exploratory analyses of immunohistochemistry pattern and genetic alterations for salivary gland cancer

Research Project

Project/Area Number	26462605
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Kobe University
Principal Investigator	Kiyota Naomi 神戸大学, 医学部附属病院, 助教 (40515037)
Research Collaborator	Otsuki Naoki 神戸大学, 大学院医学研究科外科系講座耳鼻咽喉科頭頸部外科学分野, 准教授 (40343264) ITOH Tomoo 神戸大学, 医学部附属病院病理部, 教授 (20301880) Hirai Chihoko 神戸大学, 大学院, 大学院生 NISHIO Kazuto 近畿大学, 医学部・ゲノム生物学教室, 教授 (10208134) SAKAI Kazuko 近畿大学, 医学部・ゲノム生物学教室, 助教 (20580559)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	唾液腺がん / 遺伝子変異 / 分子標的薬 / 唾液腺導管癌 / 唾液腺腺癌 / 次世代シークエンサー / 唾液腺癌 / 免疫染色 / 遺伝子異常
Outline of Final Research Achievements	Salivary adenocarcinoma was divided into two categories. One is androgen recepotor positive adenocarcinoma (APA) and the other is androgen receptor negative adenocarcinoma (ANA). Immunohistochemistry and genetic analysis revealed that APA was almost similar to salivary duct carcinoma (SDC) and ANA was quite different from both of ANA and SDC. Moreover, APA often harbored HER2 ampfilication similar to SDC. Thus, the development of therapeutic drugs for APA and SDC should be done simultaneously.And we found flt-3 mutation and RET mutation in salivary gland cancer. We already have targeting agents correspond to these mutations.So we will confirm this result in a larger cohort and investigate the clinical applicability of these novel mutation in salivary gland cancer.