Elucidating the onset mechanism and establishment of the prophylaxis of peritonsillar abscess

• Project/Area Number: 26462609
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Oita University
• Principal Investigator: Watanabe Tetsuo 大分大学, 医学部, 准教授 (50231709)
• Co-Investigator(Kenkyū-buntansha): 鈴木 正志 大分大学, 医学部, 教授 (60211314)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 扁桃周囲膿瘍 / 反復性扁桃炎 / 口蓋扁桃 / サイトカイン / リアルタイムPCR / 慢性扁桃炎 / 接着分子 / 好中球浸潤 / 口蓋扁桃被膜 / 陰窩

Outline of Final Research Achievements

The purposes of this study are to elucidate onset mechanism of peritonsillar abscess and to help establish preventive strategy of peritonsillar abscess and deep neck infection. We investigated mRNA expression of TLR2, IL-6, TNF-α, ICAM1, CD4, FOXP3, IL-17A and IL17F in palatine tonsils from patients with peritonsillar abscess and recurrent tonsillitis using real time PCR method.
The significant differences were not seen in mRNA expressions between two groups. Many patients with peritonsillar abscess do not have the history of recurrent tonsillitis. Our results suggested that there might be a cause of abscess formation in other than palatine tonsil.