Comprehensive analysis of expressed molecules in mandibular gingival cancer and elucidation of involvement of netrin 1
| Project/Area Number |
26462622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 毅 埼玉医科大学, 医学部, 准教授 (60406494)
古株 彰一郎 九州歯科大学, 歯学部, 准教授 (30448899)
自見 英治郎 九州歯科大学, 歯学部, 教授 (40276598)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯肉癌 / NKG2Dリガンド / netrin-1 / MICA/B / ALP / 骨芽細胞 / 骨吸収 / E-Cadherin |
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| Outline of Final Research Achievements |
We found that all cases of gingival cancers were positive for MICA/MICB immunostaining. We also showed that netrin-1 inhibits osteoblast differentiation and promotes osteoclast differentiation. These results suggest that MICA/MICB and netrin-1 are involved in the development of tumor and bone destruction, respectively.
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Report
(4 results)
Research Products
(2 results)
