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Comprehensive analysis of expressed molecules in mandibular gingival cancer and elucidation of involvement of netrin 1

Research Project

Project/Area Number 26462622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionSaitama Medical University

Principal Investigator

NAKAHIRA MITSUHIKO  埼玉医科大学, 医学部, 教授 (10253353)

Co-Investigator(Kenkyū-buntansha) 佐藤 毅  埼玉医科大学, 医学部, 准教授 (60406494)
古株 彰一郎  九州歯科大学, 歯学部, 准教授 (30448899)
自見 英治郎  九州歯科大学, 歯学部, 教授 (40276598)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯肉癌 / NKG2Dリガンド / netrin-1 / MICA/B / ALP / 骨芽細胞 / 骨吸収 / E-Cadherin
Outline of Final Research Achievements

We found that all cases of gingival cancers were positive for MICA/MICB immunostaining. We also showed that netrin-1 inhibits osteoblast differentiation and promotes osteoclast differentiation. These results suggest that MICA/MICB and netrin-1 are involved in the development of tumor and bone destruction, respectively.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Functional Roles of Netrin-1 in Osteoblast Differentiation.2017

    • Author(s)
      Sato T, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, Sugasawa M, Yoda T.
    • Journal Title

      In Vivo

      Volume: 31(3) Issue: 3 Pages: 321-328

    • DOI

      10.21873/invivo.11062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 1)Lower gingival squamous cell carcinoma: retrospective analysis of 32 patients treated with mandibulectomy2014

    • Author(s)
      Mitsuhiko Nakahira, Kei Morita, Fumihiko Takajo, Kazuhiko Minami, Takahiro Hayashi, Satoko Matsumura, Masashi Sugasawa
    • Organizer
      5th IFHNOS World Congress
    • Place of Presentation
      New York
    • Year and Date
      2014-07-25 – 2014-07-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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