Comprehensive analysis of expressed molecules in mandibular gingival cancer and elucidation of involvement of netrin 1

Research Project

Project/Area Number	26462622
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Saitama Medical University
Principal Investigator	NAKAHIRA MITSUHIKO 埼玉医科大学, 医学部, 教授 (10253353)
Co-Investigator(Kenkyū-buntansha)	佐藤毅埼玉医科大学, 医学部, 准教授 (60406494) 古株彰一郎九州歯科大学, 歯学部, 准教授 (30448899) 自見英治郎九州歯科大学, 歯学部, 教授 (40276598)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	歯肉癌 / NKG2Dリガンド / netrin-1 / MICA/B / ALP / 骨芽細胞 / 骨吸収 / E-Cadherin
Outline of Final Research Achievements	We found that all cases of gingival cancers were positive for MICA/MICB immunostaining. We also showed that netrin-1 inhibits osteoblast differentiation and promotes osteoclast differentiation. These results suggest that MICA/MICB and netrin-1 are involved in the development of tumor and bone destruction, respectively.

Report

(4 results)