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When and how are changes of chorioretinal blood flow caused in retinal disease?

Research Project

Project/Area Number 26462635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagoya University

Principal Investigator

Iwase Takeshi  名古屋大学, 医学部附属病院, 講師 (80642339)

Research Collaborator YAMAMOTO Kentaro  名古屋大学, 医学部附属病院, 眼科医師
RA Eimei  名古屋大学, 医学部附属病院, 眼科医師
KOBAYASHI Misato  名古屋大学, 医学部附属病院, 眼科医師
FUKAMI Marie  名古屋大学, 医学部附属病院, 眼科医師
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords眼循環 / 網脈絡膜血流
Outline of Final Research Achievements

In the study using laser speckle fluorography, it has been found that ocular blood flow has a diurnal variation in the optic nerve head and the choroid, and the optic nerve head has a strong autoregulation for maintaining the blood flow to the retina constant. I have found sex-related difference in ocular blood flow, especially at the optic nerve head and female has higher blood flow than male. I have succeeded in visualizing the blood flow velocity state in the retinal blood vessels and found that the blood flow state differs between arteries and veins of retinal blood vessels. I has been found that choroidal luminal area and age are significantly correlated with choroidal blood flow. It has bee elucidated that retinal blood flow is reduced before surgery in eyes with rhegmatogenous retinal detachment and it can be increase following retinal re-attachment.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (31 results)

All 2017 2016 2015 2014

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 18 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries.2017

    • Author(s)
      Kaneko H, Asami T, Sugita T, Tsunekawa T, Matsuura T, Takayama K, Yamamoto K, Kachi S, Ito Y, Ueno S, Nonobe N, Kataoka K, Suzumura A, Iwase T, Terasaki H.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 1 Pages: e0170094-e0170094

    • DOI

      10.1371/journal.pone.0170094

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy.2017

    • Author(s)
      Nagasaka Y, Kaneko H, Ye F, Kachi S, Asami T, Kato S, Takayama K, Hwang SJ, Kataoka K, Shimizu H, Iwase T, Funahashi Y, Higuchi A, Senga T, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58 Issue: 1 Pages: 221-229

    • DOI

      10.1167/iovs.16-20513

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regeneration of Photoreceptor Outer Segments after Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment.2017

    • Author(s)
      Ra E, Ito Y, Kawano K, Iwase T, Kaneko H, Ueno S, Yasuda S, Kataoka K, Terasaki H.
    • Journal Title

      Am J Ophthalmol.

      Volume: 177 Pages: 17-26

    • DOI

      10.1016/j.ajo.2017.01.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion.2017

    • Author(s)
      Fukami M, Iwase T, Yamamoto K, Kaneko H, Yasuda S, Terasaki H.
    • Journal Title

      Biomed Res Int.

      Volume: 58 Issue: 2 Pages: 1246-1255

    • DOI

      10.1167/iovs.16-21115

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment.2017

    • Author(s)
      Tsunekawa T, Kaneko H, Takayama K, Hwang SJ, Oishi A, Nagasaka Y, Ye F, Iwase T, Nonobe N, Ueno S, Ito Y, Yasuda S, Matsuura T, Shimizu H, Suzumura A, Kataoka K, Terasaki H.
    • Journal Title

      Biomed Res Int.

      Volume: 2017 Pages: 3427319-3427319

    • DOI

      10.1155/2017/3427319

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of photocoagulation on ocular blood flow in patients with severe non-proliferative diabetic retinopathy.2017

    • Author(s)
      Iwase T, Kobayashi M, Yamamoto K, Ra E, Terasaki H.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: e0174427-e0174427

    • DOI

      10.1371/journal.pone.0174427

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased ocular levels of microRNA-148a in cases of retinal detachment promote epithelial- mesenchymal transition.2016

    • Author(s)
      Takayama K, Kaneko H, Hwang SJ, Ye F, Higuchi A, Tsunekawa T, Matsuura T, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Nonobe N, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 6 Pages: 2699-2705

    • DOI

      10.1167/iovs.15-18660

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in blood flow on optic nerve head after vitrectomy for rhegmatogenous retinal detachment.2016

    • Author(s)
      Iwase T, Kobayashi M, Yamamoto K, Yanagida K, Ra E, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 14 Pages: 6223-6233

    • DOI

      10.1167/iovs.16-20577

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change in refraction after lens-sparing vitrectomy for rhegmatogenous retinal detachment and epiretinal membrane.2016

    • Author(s)
      Iwase T, Yamamoto K, Yanagida K, Kobayashi M, Ra E, Murotani K, Terasaki H.
    • Journal Title

      Medicine (Baltimore).

      Volume: 95 Issue: 32 Pages: e4317-e4317

    • DOI

      10.1097/md.0000000000004317

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Endovascular Cannulation Needle with an Internal Wire for the Fragmentation of Thrombi in Retinal Vein Occlusion.2016

    • Author(s)
      Asami T, Kaneko H, Miyake K, Ota I, Miyake G, Kato S, Yasuda S, Iwase T, Ito Y, Terasaki H.
    • Journal Title

      Transl Vis Sci Technol

      Volume: 5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pyramidal-Shaped Residual Subretinal Fluid at Fovea After Intravitreal Injection of Perfluoro-n-Octane in Eyes With Fovea-Off Rhegmatogenous Retinal Detachment.2016

    • Author(s)
      Iwase T, Ra E, Asami T, Yamamoto K, Kaneko H, Terasaki H.
    • Journal Title

      Retina

      Volume: 36

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] What ocular and systemic variables affect choroidal circulation in healthy eyes.2016

    • Author(s)
      Iwase T, Yamamoto K, Kobayashi M, Ra E, Murotani K, Terasaki H.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term changes in intraocular pressure after vitrectomy for rhegmatogenous retinal detachment, epi-retinal membrane, or macular hole.2016

    • Author(s)
      Yamamoto K, Iwase T, Terasaki H.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 11 Pages: e0167303-e0167303

    • DOI

      10.1371/journal.pone.0167303

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment.2016

    • Author(s)
      Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 3 Pages: 889-98

    • DOI

      10.1167/iovs.15-18403

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical Videos with Synchronised Vertical 2-Split Screens Recording the Surgeons' Hand Movement.2015

    • Author(s)
      Kaneko H, Ra E, Kawano K, Yasukawa T, Takayama K, Iwase T, Terasaki H.
    • Journal Title

      Ophthalmologica

      Volume: 234 Issue: 4 Pages: 243-6

    • DOI

      10.1159/000439119

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects.2015

    • Author(s)
      Iwase T, Ra E, Yamamoto K, Kaneko H, Ito Y, Terasaki H.
    • Journal Title

      Medicine (Baltimore)

      Volume: 94 Issue: 33 Pages: 1-8

    • DOI

      10.1097/md.0000000000001256

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy.2015

    • Author(s)
      Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56 Issue: 8 Pages: 4880-90

    • DOI

      10.1167/iovs.15-16567

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow2015

    • Author(s)
      Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H.
    • Journal Title

      Medicine (Baltimore)

      Volume: Feb;94(6) Issue: 6 Pages: e519-e519

    • DOI

      10.1097/md.0000000000000519

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in retinochoroidal thickness after vitrectomy for proliferative diabetic retinopathy2015

    • Author(s)
      Yamamoto K, Iwase T, Ushida H, Sugita T, Terasaki H
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Relationship between choroidal circulation and ocular and systemic variables in healthy eyes.2016

    • Author(s)
      Takeshi Iwase, Kentaro Yamamoto, Misato Kobayashi, Eimei Ra, Hiroko Terasaki
    • Organizer
      ARVO
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between photoreceptor restoration and visual acuity following surgery for rhegmatogenous retinal detachment2016

    • Author(s)
      Takeshi Iwase
    • Organizer
      1st Japan-Taiwan Vitreoretinal Joint Meeting
    • Place of Presentation
      Taipei, Tiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Laser speckle flowgraphyによる眼血流測定の性差と全身循環,血液生化学検査との関連2015

    • Author(s)
      岩瀬 剛,羅 英明,山本健太郎,伊藤逸毅,寺崎浩子
    • Organizer
      第32回日本眼循環学会
    • Place of Presentation
      東京国際フォーラム,東京都千代田区
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Change of refraction after lens-sparing vitrectomy for rhegmatogenous retinal detachment.2015

    • Author(s)
      Takeshi Iwase, Hiroko Terasaki.
    • Organizer
      15th EURETINA Congress
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Takeshi Iwase, Eimei Ra, Kentaro Yamamoto, Hiroko Terasaki2015

    • Author(s)
      Differences between arteries and veins of retinal blood flow determined by laser speckle flowgraphy in healthy eyes
    • Organizer
      The association for research in vision and ophthalmology
    • Place of Presentation
      Denver, Co, USA
    • Year and Date
      2015-05-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Differences between arteries and veins of retinal blood flow determined by laser speckle flowgraphy in healthy eyes.2015

    • Author(s)
      Takeshi Iwase, Eimei Ra, Kentaro Yamamoto, Hiroko Terasaki.
    • Organizer
      The association for research in vision and ophthalmology
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] レーザースペックルフローグラフィによる血流測定における性差と眼血流の関連について2015

    • Author(s)
      岩瀬 剛,羅 英明,山本健太郎,伊藤逸毅,寺崎浩子
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌,北海道札幌市
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 硝子体手術前後の毛様体脈絡膜厚2014

    • Author(s)
      岩瀬 剛
    • Organizer
      第9回脈絡膜画像研究会
    • Place of Presentation
      大阪府大阪市 大阪国際会議場
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] レーザースペックルフローグラフィによる網膜動静脈血流測定2014

    • Author(s)
      岩瀬 剛,羅 英明,山本健太郎,古林充里,伊藤逸毅,寺崎浩子
    • Organizer
      第31回日本眼循環学会
    • Place of Presentation
      大阪府大阪市 大阪国際会議場
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 正常人における高濃度酸素負荷に対する視神経乳頭部および脈絡膜血流の自己調節機能の検討2014

    • Author(s)
      岩瀬 剛、山本健太郎、羅 英明、川野健一、寺崎浩子
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      兵庫県神戸市 ポートピアホテル
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 黄斑前膜、黄斑円孔、網膜剥離に対する硝子体手術後の長期眼圧経過2014

    • Author(s)
      岩瀬 剛,山本健太郎,古林充里,寺崎浩子
    • Organizer
      第35回東海緑内障の会
    • Place of Presentation
      愛知県名古屋市 東建ホール丸の内
    • Year and Date
      2014-08-02
    • Related Report
      2014 Research-status Report
  • [Book] 網膜剥離と極小切開硝子体手術2015

    • Author(s)
      岩瀬 剛,寺崎浩子,杉田 糾,國方彦志,田中住美,河村 肇,近藤寛之,喜多美穂里,浅見 哲,前野貴俊,瓶井資弘,日下俊次,國吉一樹,池田恒彦,引地泰一,荻野 顕,上野真治,木村英也,松原 央,若林 卓,兼子裕規,山城健児,廣田和成,平形明人,大石明生,北岡 隆,大岩和博,伊藤逸毅,産賀 真,大島佑介,井上 真ら
    • Total Pages
      369
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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