When and how are changes of chorioretinal blood flow caused in retinal disease?
| Project/Area Number |
26462635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
Iwase Takeshi 名古屋大学, 医学部附属病院, 講師 (80642339)
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| Research Collaborator |
YAMAMOTO Kentaro 名古屋大学, 医学部附属病院, 眼科医師
RA Eimei 名古屋大学, 医学部附属病院, 眼科医師
KOBAYASHI Misato 名古屋大学, 医学部附属病院, 眼科医師
FUKAMI Marie 名古屋大学, 医学部附属病院, 眼科医師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 眼循環 / 網脈絡膜血流 |
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| Outline of Final Research Achievements |
In the study using laser speckle fluorography, it has been found that ocular blood flow has a diurnal variation in the optic nerve head and the choroid, and the optic nerve head has a strong autoregulation for maintaining the blood flow to the retina constant. I have found sex-related difference in ocular blood flow, especially at the optic nerve head and female has higher blood flow than male. I have succeeded in visualizing the blood flow velocity state in the retinal blood vessels and found that the blood flow state differs between arteries and veins of retinal blood vessels. I has been found that choroidal luminal area and age are significantly correlated with choroidal blood flow. It has bee elucidated that retinal blood flow is reduced before surgery in eyes with rhegmatogenous retinal detachment and it can be increase following retinal re-attachment.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries.2017
Author(s)
Kaneko H, Asami T, Sugita T, Tsunekawa T, Matsuura T, Takayama K, Yamamoto K, Kachi S, Ito Y, Ueno S, Nonobe N, Kataoka K, Suzumura A, Iwase T, Terasaki H.
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Journal Title
PLoS One
Volume: 12
Issue: 1
Pages: e0170094-e0170094
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy.2017
Author(s)
Nagasaka Y, Kaneko H, Ye F, Kachi S, Asami T, Kato S, Takayama K, Hwang SJ, Kataoka K, Shimizu H, Iwase T, Funahashi Y, Higuchi A, Senga T, Terasaki H.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 58
Issue: 1
Pages: 221-229
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment.2017
Author(s)
Tsunekawa T, Kaneko H, Takayama K, Hwang SJ, Oishi A, Nagasaka Y, Ye F, Iwase T, Nonobe N, Ueno S, Ito Y, Yasuda S, Matsuura T, Shimizu H, Suzumura A, Kataoka K, Terasaki H.
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Journal Title
Biomed Res Int.
Volume: 2017
Pages: 3427319-3427319
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased ocular levels of microRNA-148a in cases of retinal detachment promote epithelial- mesenchymal transition.2016
Author(s)
Takayama K, Kaneko H, Hwang SJ, Ye F, Higuchi A, Tsunekawa T, Matsuura T, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Nonobe N, Terasaki H.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 57
Issue: 6
Pages: 2699-2705
DOI
Related Report
Peer Reviewed / Open Access
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