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Development of new drug delivery systems in ophthalmology using bionanosheet

Research Project

Project/Area Number 26462682
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KASHIWAGI KENJI  山梨大学, 総合研究部, 准教授 (30194723)

Co-Investigator(Kenkyū-buntansha) 武岡 真司  早稲田大学, 理工学術院, 教授 (20222094)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsdrug delivery system / 緑内障 / ドラックデリバリーシステム / バイオナノシート / 手術補助剤 / 眼科
Outline of Final Research Achievements

We developed various types of bionanosheets and investigated the possibility of these for the following subjects; layer-by-layer structured bionanosheet from anion membrane and cation membrane, constructed from poly-lactic acid, and hybrid of these two bionanosheet. We investigated adhesive strength to the ocular tissues and drug releasing profile, of these bionanosheet. We investigated these bionanosheet regarding usefulness and safety in clinically applicable three fields; sustained intraocular reduction, supplemental agent for filtering surgery, and no-suture wound closure.
In conclusions, we confirmed assembled bionanosheet could control reasonable drug release profile, improving filtering surgery results, and close corneal wound without suture.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014

All Journal Article (14 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 14 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Efficacy and Safety of Switching Latanoprost Monotherapy to Bimatoprost Monotherapy or Combination of Brinzolamide and Latanoprost2016

    • Author(s)
      Imasawa M, Tanabe J, Kashiwagi F, Kashiwagi K.
    • Journal Title

      Open Ophthalmol J

      Volume: 7 Issue: 1 Pages: 94-102

    • DOI

      10.2174/1874364101610010094

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study.2016

    • Author(s)
      Nishisako M, Meguro A, Nomura E, Yamane T, Takeuchi M, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A(6), Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Ophthalmic Genet

      Volume: 37 Issue: 2 Pages: 197-200

    • DOI

      10.3109/13816810.2015.1028649

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG).2016

    • Author(s)
      Fujino Y, Asaoka R, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 4 Pages: 2012-2020

    • DOI

      10.1167/iovs.15-19046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel method to predict visual field progression more accurately, using intraocular pressure measurements in glaucoma patients2016

    • Author(s)
      Asaoka R, Fujino Y, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N, Japanese Archive of Multicentral Database in Glaucoma (JAMDIG) construction group
    • Journal Title

      Sci Rep

      Volume: 26 Issue: 1 Pages: 31728-31728

    • DOI

      10.1038/srep31728

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors.2016

    • Author(s)
      Asaoka R, Murata H, Fujino Y, Hirasawa K, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Miki A, Shoji N
    • Journal Title

      Br J Ophthalmol.

      Volume: - Issue: 8 Pages: 1071-1075

    • DOI

      10.1136/bjophthalmol-2016-309643

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C.2016

    • Author(s)
      Kashiwagi K, Kogure S, Mabuchi F, Chiba T, Yamamoto T, Kuwayama Y, Araie M; Collaborative Bleb-Related Infection Incidence and Treatment Study Group.
    • Journal Title

      Acta Ophthalmologica

      Volume: 94 Issue: 7 Pages: 561-570

    • DOI

      10.1111/aos.13058

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of the associations between changes in intraocular pressure and metabolic syndrome parameters: a retrospective cohort study in Japan2016

    • Author(s)
      Yokomichi H, Kashiwagi K, Kitamura K, Yoda Y, Tsuji M, Mochizuki M, Sato M, Mizorogi S, Shinohara R, Suzuki K and Yamagata Z
    • Journal Title

      BMJ Open

      Volume: 6 Issue: 3 Pages: 10360-10360

    • DOI

      10.1136/bmjopen-2015-010360

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Treatment Patterns and Health Care Costs for Age-Related Macular Degeneration in Japan: An Analysis of National Insurance Claims Data.2016

    • Author(s)
      Kume A, Ohshiro T, Sakurada Y, Kikushima W, Yoneyama S, Kashiwagi K
    • Journal Title

      Ophthalmology

      Volume: 123 Issue: 6 Pages: 1263-1268

    • DOI

      10.1016/j.ophtha.2016.01.042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Current Status of Mitomycin C-Augmented Trabeculectomy in Japan Based on Collaborative Bleb-Related Infection Incidence and Treatment Study2016

    • Author(s)
      K Kashiwagi, K Kitamura, F Mabuchi, T Chiba S Kogure
    • Journal Title

      EC ophthalmology

      Volume: 4 Pages: 553-562

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Treatment Patterns and Health Care Costs for Age-Related Macular Degeneration in Japan: An Analysis of National Insurance Claims Data.2016

    • Author(s)
      Kume A, Ohshiro T, Sakurada Y, Kikushima W, Yoneyama S, Kashiwagi K.
    • Journal Title

      Ophthalmology.

      Volume: 16 Pages: 148-152

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study.2016

    • Author(s)
      Nishisako M, Meguro A, Nomura E, Yamane T, Takeuchi M, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N.
    • Journal Title

      Ophthalmic Genet.

      Volume: 37 Pages: 194-200

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Collaborative Bleb-Related Infection Incidence and Treatment Study Group. Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C2016

    • Author(s)
      Kashiwagi K, Kogure S, Mabuchi F, Chiba T, Yamamoto T, Kuwayama Y, Araie M
    • Journal Title

      Acta Ophthalmol

      Volume: in press Issue: 6 Pages: 657-664

    • DOI

      10.1111/den.12678

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y(6) receptor signals.2015

    • Author(s)
      Taguchi M, Shinozaki Y, Kashiwagi K, Shigetomi E, Robaye B, Koizumi S.
    • Journal Title

      J Neurochem.

      Volume: 12 Issue: 4 Pages: 1-5

    • DOI

      10.1111/jnc.13427

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma.2015

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 149 Pages: 437-444

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 新しい緑内障治療に向けたDDSの在り方2017

    • Author(s)
      柏木賢治
    • Organizer
      第121回日本眼科学会
    • Place of Presentation
      国際フォーラム 東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 点眼薬治療からの脱却2016

    • Author(s)
      柏木賢治
    • Organizer
      日本緑内障学会
    • Place of Presentation
      インターコンチネンタル 横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] 眼圧下降のドラックデリバリー2015

    • Author(s)
      柏木賢治
    • Organizer
      日本眼科学会
    • Place of Presentation
      北海道、札幌、札幌記念音楽堂
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 眼圧下降薬のドラッグデリバリー2015

    • Author(s)
      柏木賢治
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] ナノシート素材を活用した新しい眼科ドラックデリバリーシステムの開発2014

    • Author(s)
      柏木賢治
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京、東京フォーラム
    • Year and Date
      2014-04-02
    • Related Report
      2014 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 医用製剤2014

    • Inventor(s)
      武岡真司、柏木賢治、藤枝俊宣、齋藤晃広、羽生田博貴
    • Industrial Property Rights Holder
      武岡真司、柏木賢治、藤枝俊宣、齋藤晃広、羽生田博貴
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-28
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2018-03-22  

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