Development of new drug delivery systems in ophthalmology using bionanosheet
| Project/Area Number |
26462682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
武岡 真司 早稲田大学, 理工学術院, 教授 (20222094)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | drug delivery system / 緑内障 / ドラックデリバリーシステム / バイオナノシート / 手術補助剤 / 眼科 |
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| Outline of Final Research Achievements |
We developed various types of bionanosheets and investigated the possibility of these for the following subjects; layer-by-layer structured bionanosheet from anion membrane and cation membrane, constructed from poly-lactic acid, and hybrid of these two bionanosheet. We investigated adhesive strength to the ocular tissues and drug releasing profile, of these bionanosheet. We investigated these bionanosheet regarding usefulness and safety in clinically applicable three fields; sustained intraocular reduction, supplemental agent for filtering surgery, and no-suture wound closure.
In conclusions, we confirmed assembled bionanosheet could control reasonable drug release profile, improving filtering surgery results, and close corneal wound without suture.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study.2016
Author(s)
Nishisako M, Meguro A, Nomura E, Yamane T, Takeuchi M, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A(6), Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N
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Journal Title
Ophthalmic Genet
Volume: 37
Issue: 2
Pages: 197-200
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG).2016
Author(s)
Fujino Y, Asaoka R, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 57
Issue: 4
Pages: 2012-2020
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A novel method to predict visual field progression more accurately, using intraocular pressure measurements in glaucoma patients2016
Author(s)
Asaoka R, Fujino Y, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N, Japanese Archive of Multicentral Database in Glaucoma (JAMDIG) construction group
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Journal Title
Sci Rep
Volume: 26
Issue: 1
Pages: 31728-31728
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors.2016
Author(s)
Asaoka R, Murata H, Fujino Y, Hirasawa K, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Miki A, Shoji N
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Journal Title
Br J Ophthalmol.
Volume: －
Issue: 8
Pages: 1071-1075
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study.2016
Author(s)
Nishisako M, Meguro A, Nomura E, Yamane T, Takeuchi M, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N.
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Journal Title
Ophthalmic Genet.
Volume: 37
Pages: 194-200
Related Report
Peer Reviewed / Int'l Joint Research
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