Development of neuroprotective treatment for glaucoma with scleral crossing around the optic nerve head
| Project/Area Number |
26462686
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
臼井 審一 大阪大学, 医学部附属病院, その他 (20546882)
相馬 剛至 大阪大学, 医学系研究科, 助教 (70582401)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | クロスリンキング / 緑内障 / 紫外線 / 篩状板 / 神経保護 / 眼医工学 |
|---|
| Outline of Final Research Achievements |
Glaucoma is now understood as a chronic multifactorial disease which progresses with numerous risk factors such as circulatory disorders other than ocular pressure, vulnerability of lamina cribrosa, heredity, immunity and the like. Particularly attention is paid to the vulnerability of the lamina cribrosa and the tissue around the optic disc that support the optic nerve head. Here, to treat glaucoma, we are developing the cross-linking therapy, which is clinically applied to keratoconus, and attracting attention as a treatment for myopia to the pericapillary sclera. We confirm the effectiveness to biological safety and increase of scleral strength. Furthermore, the efficacy of neuroprotective effect is confirmed with a intra ocular hypertensive model mouse.
|
Report
(5 results)
Research Products
(21 results)
-
-
-
-
-
[Journal Article] Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma.2016
Author(s)
Rong SS, Chen LJ, Leung CK, Matsushita K, Jia L, Miki A, Chiang SW, Tam PO, Hashida N, Young AL, Tsujikawa M, Zhang M, Wang N, Nishida K, Pang CP.
-
Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 27837-27837
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] A case of aniridia with a heterozygous PAX6 mutation whose pituitary function was partially impaired.2014
Author(s)
Shimo N, Yasuda T, Kitamura T, Matsushita K, Osawa S, Yamamoto Y, Kozawa J, Otsuki M, Funahashi T, Imagawa A, Kaneto H, Nishida K, Shimomura I.
-
Journal Title
Internal medicine
Volume: 53
Pages: 39-42
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
