| Project/Area Number |
26462747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
矢作 直樹 東京大学, 医学部附属病院, 教授 (60158045)
内田 寛治 東京大学, 医学部附属病院, 准教授 (60302709)
土井 研人 東京大学, 医学部附属病院, 特任講師 (80505892)
小宮山 雄介 獨協医科大学, 医学部, 助教 (90586471)
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| Research Collaborator |
HIRUMA Takahiro 東京大学, 医学部附属病院, 助教 (40572277)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 敗血症 / 急性腎障害 / 免疫抑制 / 院内感染症 / バイオマーカー |
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| Outline of Final Research Achievements |
We evaluate therapeutic possibility of IFNb on murine model of septic pneumonia. Murine sepsis was induced by cecal ligation and puncture (CLP) on mice. Four days later, pneumonia was made with intratracheal instillation of Pseudomonas aeruginosa. IFNb was given 24 hours before PA instillation. Survival was observed. Bronchoalveolar lavage (BAL) was done at 18 hours after PA instillation and remaining bacterial count, cell count, cytokine levels in the BALF were evaluated. Survival was significantly worse on murine model of septic pneumonia. Administration of IFNb significantly improved survival. TNFa and IL-6 in the BALF tended to be higher and remaining bacterial count tended to be lower in group treated by IFNb.Impaired host defense mechanism might associate with higher mortality in septic pneumonia mouse model. Subcutaneous IFNb may restore production of inflammatory cytokines in the lung and increased neutrophil recruitment and that may contribute to improve survival.
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