| Project/Area Number |
26462748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Aiboshi Junichi 東京医科歯科大学, 医学部附属病院, 講師 (50256913)
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| Co-Investigator(Kenkyū-buntansha) |
小林 哲幸 お茶の水女子大学, 基幹研究院, 教授 (50178323)
柴田 政廣 芝浦工業大学, システム理工学部, 教授 (60158954)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ホスホリパーゼA2 / カルシウム非依存性ホスホリパーゼA2 / 好中球 / 急性炎症 / 多臓器障害 / 出血性ショック / 血管内皮細胞 / 多臓器傷害 |
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| Outline of Final Research Achievements |
Phospholipase A2 (PLA2) consists of secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and calcium independent PLA2 (iPLA2). Compared to sPLA2 and cPLA2, roles of the iPLA2 enzyme in acute inflammation remain ill defined. Our current studies have demonstrated that iPLA2γ may be involved in multiple neutrophil cytotoxic functions (extracellular superoxide production, degranulation, chemotaxis, adhesion, adhesion molecule surface expression) as well as the leukocyte-endothelial cell interaction in rat mesenteric microcirculation. Thus the iPLA2γ enzyme may be essential for acute inflammatory process. In addition, iPLA2γ-associated metabolites other than arachidonic acid are likely to be signaling molecules of neutrophil cytotoxicity.
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