| Project/Area Number |
26462779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川端 重忠 大阪大学, 歯学研究科, 教授 (50273694)
住友 倫子 大阪大学, 歯学研究科, 助教 (50423421)
岡橋 暢夫 大阪大学, 歯学研究科, 准教授 (40150180)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 化膿レンサ球菌 / 線毛 / レンサ球菌 |
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| Outline of Final Research Achievements |
The human pathogen group A Streptococcus pyogenes causes a wide variety of diseases, ranging from superficial purulent infections of the pharynx and skin to invasive infections. During the pathological process, Streptococcus pyogenes senses diverse environmental and host factors, and exhibits modulation of secretory proteins. We examined whether environmental temperature has effects on pilus expression of S. pyogenes. Experiments using clinically relevant serotypes revealed that strains possessing distinct genotypes of a chromosomal region showed temperature-dependent pilus expression, which was attributed to translation efficiency of a transcriptional regulator. Thus, the findings indicate that Streptococcus pyogenes responds to environmental temperature and modulates expression of adhesins.
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