Study on the pathogenicity of dental biofilm by molecular genetic technics
| Project/Area Number |
26462801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Hamada Nobushiro 神奈川歯科大学, 大学院歯学研究科, 教授 (20247315)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 俊介 神奈川歯科大学, 大学院歯学研究科, 准教授 (60206810)
渡辺 清子 神奈川歯科大学, 大学院歯学研究科, 講師 (70148021)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | グラム陽性桿菌 / Actinomyces naeslundii / バイオフィルム / 歯周炎 / 通性嫌気性グラム陽性桿菌 / 共凝集 / 歯槽骨吸収 / サイトカイン / 破骨細胞 |
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| Outline of Final Research Achievements |
A. naeslundii peptidoglycan induces the production of inflammatory cytokines and activates osteoclasts in alveolar bone resorption. Expressions of IL-1β, IL-6, and TNF-α mRNA were apparent in BALB/c mouse peritoneal macrophages stimulated with A. naeslundii PGN. In experimental periodontitis, the oral challenge of A. naeslundii resulted in the induction of alveolar bone loss in rats. These results suggest that peptidoglycan of A. naeslundii is an important virulence factor in the development of periodontitis. We could not succeed in the mutation of A. naeslundii fimbriae, however titanium oxide photocatalytic properties contribute to the reduction of bacterial biofilms and aid in the prevention of periodontal diseases.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP).2016
Author(s)
Funaki S, Tokutomi F, Wada-Takahashi S, Yoshino F, Yoshida A, Maehata Y, Miyamoto C, Toyama T, Sato T, Hamada N, Lee M-C, Takahashi S-S
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Journal Title
Microbial Pathogenesis
Volume: 92
Pages: 36-42
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016
Author(s)
Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 58
Issue: 1
Pages: 69-75
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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