| Project/Area Number |
26462801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Hamada Nobushiro 神奈川歯科大学, 大学院歯学研究科, 教授 (20247315)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 俊介 神奈川歯科大学, 大学院歯学研究科, 准教授 (60206810)
渡辺 清子 神奈川歯科大学, 大学院歯学研究科, 講師 (70148021)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | グラム陽性桿菌 / Actinomyces naeslundii / バイオフィルム / 歯周炎 / 通性嫌気性グラム陽性桿菌 / 共凝集 / 歯槽骨吸収 / サイトカイン / 破骨細胞 |
|---|
| Outline of Final Research Achievements |
A. naeslundii peptidoglycan induces the production of inflammatory cytokines and activates osteoclasts in alveolar bone resorption. Expressions of IL-1β, IL-6, and TNF-α mRNA were apparent in BALB/c mouse peritoneal macrophages stimulated with A. naeslundii PGN. In experimental periodontitis, the oral challenge of A. naeslundii resulted in the induction of alveolar bone loss in rats. These results suggest that peptidoglycan of A. naeslundii is an important virulence factor in the development of periodontitis. We could not succeed in the mutation of A. naeslundii fimbriae, however titanium oxide photocatalytic properties contribute to the reduction of bacterial biofilms and aid in the prevention of periodontal diseases.
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