| Project/Area Number |
26462812
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Sogawa Chiharu 岡山大学, 医歯薬学総合研究科, 講師 (10253022)
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| Co-Investigator(Kenkyū-buntansha) |
十川 紀夫 松本歯科大学, 歯学部, 教授 (30236153)
森田 克也 広島文化学園大学, 看護学部, 教授 (10116684)
小崎 健一 岡山大学, 医歯薬学総合研究科, 教授 (50270715)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 疼痛治療薬 / 神経障害性疼痛 / モノアミントランスポーター / GABAトランスポーター / ﾓﾉｱﾐﾝﾄﾗﾝｽﾎﾟｰﾀｰ / GABAﾄﾗﾝｽﾎﾟｰﾀｰ |
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| Outline of Final Research Achievements |
Neuropathic pain is defined with for a chronic or persistent pain to be generated by a pathophysiological alteration on the peripheral and/or central nervous system. Antidepressants are known as the inhibitors of monoamine neurotransmitter transporters (MAT) are therapeutically useful ligands for the treatment of neuropathic pain. However, they do not sometimes provide enough effects. In this study, we were aimed for the development of an effective therapeutic drug for neuropathic pain. We focused on the inhibition of MAT or GABA transporters (GAT). One of GAT inhibitors that display moderate selectivity for GAT, had an antiallodynic action on neuropathic pain model mice. The antiallodynic action of the GAT inhibitor is due to the inhibition of both GAT and MAT. We also observed how an expression of MAT change after the neuropathic pain onset influences an antiallodynic action. In this study, we confirmed that the change of MAT expression and antiallodynic effect included correlation.
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